Abstract
Hemodynamics can be defined as the part of cardiovascular physiology dealing with the forces that drive the blood circulation in mammalian cardiovascular systems. A cardiovascular system is a series of blood vessels connected to the heart. Pressure generated in the heart propels blood through the system continuously. In this chapter, basic hemodynamics essential to interpretation of arterial disease in the aspect of bio-fluid mechanics are introduced. Hemodynamics in bio-fluid mechanics plays an important role in better understanding of clinical and pathological observations and in developing new methods for diagnosis in connection with mathematical models. In particular, hemodynamic factors, such as Wall Shear Stress and Oscillatory Shear Index, correlate substantially with the generation and progression of arterial disease including intimal thickening and atherosclerosis. In the larger vessels, such as the carotid artery, interaction between the vessel wall and the blood flow affects the distribution of hemodynamic factors.
The main scope of this chapter is to introduce hemodynamic applications of mathematical modeling of fluid mechanics. Mathematical models of fluid mechanics are used to quantify the hemodynamic factors and their relationship to vascular disease. The majority of all cardiovascular diseases and disorders are related to systemic hemodynamic dysfunction. Recent studies of cardiovascular diseases in relation to hemodynamic dysfunction are also briefly reviewed.
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Ajmani RS (1997) Hypertension and hemorheology. Clin Hemorheol Microcirc 17:397–420
Bor-Kucukkatay M, Yalcin O, Gokalp O et al (2000) Red blood cell rheological alterations in hypertension induced by chronic inhibition of nitric oxide synthesis in rats. Clin Hemorheol Microcirc 22:267–275
Chien S (2003) Molecular mechanical bases of focal lipid accumulation in arterial wall. Prog Biophys Mol Biol 83:131–151
Chien S, Dormandy J et al (eds) (1987) Clinical hemorheology. Martinus Nijhoff Publishers, Dordrecht
Clark JM, Glagov S (1985) Transmural organization of the arterial media: the lamellar unit revisited. Arterioscler Thromb Vasc Biol 5:19–34. doi:10.1161/01.ATV.5.1.19
Fung YC (1993) Biomechanics: mechanical properties of living tissues, 2nd edn. Springer, New York
Huang Y, Jan KM, Rumschitzki D et al (1998) Structural changes in rat aortic intima due to transmural pressure. Trans ASME J Biomech Eng 120:476–483
Kesmarky G, Toth K, Habon L et al (1998) Hemorheological parameters in coronary artery disease. Clin Hemorheol Microcirc 18:245–251
Kleinstreuer C (2006) Biofluid dynamics: principles and selected applications. CRC Press, Boca Raton
Kohler TR, Jawien A (1992) Flow affects development of intimal hyperplasia after arterial injury in rats. Arterioscler Thromb 12:963–971
Ku DN, Giddens DP et al (1985) Pulsatile flow and atherosclerosis in the human carotid bifurcation: positive correlation between plaque location and low oscillating shear stress. Arteriosclerosis 5:293–302
Levick JR (1987) Relation between hydraulic resistance and composition of the interstitium. Adv Microcirc 13:124–133
Lipowsky HH (1995) Shear stress in the circulation. In: Bevan JA et al (eds) Flow-dependent regulation of vascular function. Oxford University Press, New York
McMillan DE (1993) Hemorheological studies in the diabetes control and complications trial. Clin Hemorheol 13:147–154
Merrill EW (1969) Rheology of blood. Physiol Rev 49(4):863–888
Morris CL, Rucknagel DL et al (1989) Evaluation of the yield stress of normal blood as a function of fibrinogen concentration and hematocrit. Microvasc Res 37(3):323–338
Ramakrishnan S, Grebe R et al (1999) Aggregation of shape altered erythrocytes: an in vitro study. Curr Sci 77:805–808
Shi ZD, Tarbell JM (2011) Fluid flow mechanotransduction in vascular smooth muscle cells and fibroblasts. Ann Biomed Eng 39(6):1608–1619
Shi ZD, Ji XY, Qazi H et al (2009) Interstitial flow promotes vascular fibroblast, myofibroblast, and smooth muscle cell motility in 3-D collagen I via upregulation of MMP-1. Am J Physiol Heart Circ Physiol 297(4):H1225–H1234
Shi ZD, Wang H et al (2011) Heparan sulfate proteoglycans mediate interstitial flow mechanotransduction regulating MMP-13 expression and cell motility via FAK-ERK in 3D collagen. PLos One. doi:10.1371/journal.pone.0015956
Shul’man ZP, Mansurov VA et al (2006) Rheological changes in the blood and plasma of patients with myocardial ischemia and diabetes mellitus and dysfunction of their endothelium. J Eng Phys Thermophys 79(1):99–104
Tada S, Ozono H (2011) Computational study of LDL mass transport in the artery wall. J Biorheol 25(1–2):27–35
Tada S, Tarbell JM (2000) Interstitial flow through the internal elastic lamina affects shear stress on arterial smooth muscle cells. Am J Physiol Heart Circ Physiol 278:H1589–H1597
Tada S, Tarbell JM (2002) Flow through internal elastic lamina affects shear stress on smooth muscle cells (3D simulations). Am J Physiol Heart Circ Physiol 282:H576–H584
Tada S, Tarbell JM (2005) A computational study of flow in a compliant carotid bifurcation – stress phase angle correlation with shear stress. Ann Biomed Eng 33:1202–1212
Tarbell JM, Shi ZD (2013) Effect of the glycocalyx layer on transmission of interstitial flow shear stress to embedded cells. Biomech Model Mechanobiol 12(1):111–121. doi:10.1007/s10237-012-0385-8
Tarbell JM, Shi ZD et al (2014) Fluid mechanics, arterial disease, and gene expression. Annu Rev Fluid Mech 46:591–614. doi:10.1146/annurev-fluid-010313-141309
Tedgui A, Lever MJ (1984) Filtration through damaged and undamaged rabbit thoracic aorta. Am J Physiol Heart Circ Physiol 247:H784–H791
Thomas JB, Milner JS et al (2002) On the influence of vessel planarity on local hemodynamics at the human carotid bifurcation. Biorheology 39:443–448
Wang DM, Tarbell JM (1995) Modeling interstitial flow in an artery wall allows estimation of wall shear stress on smooth muscle cells. Trans ASME J Biomech Eng 117:358–363
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Tada, S., Tarbell, J.M. (2016). Hemodynamics in Physio- and Pathological Vessels. In: Tanishita, K., Yamamoto, K. (eds) Vascular Engineering. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54801-0_4
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DOI: https://doi.org/10.1007/978-4-431-54801-0_4
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