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Schwann Cell Development and Pathology pp 29–45Cite as

Membrane Skeleton in Schmidt–Lanterman Incisure in Schwann Cells of the Peripheral Nervous System

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Abstract

Schmidt–Lanterman incisure (SLI), a truncated cone–shape in a myelin internode, is a specific feature of myelinated nerve fibers in the peripheral nervous system (PNS). In this review, we focus on the membrane skeleton in SLI. First, we describe a membrane skeletal protein, 4.1G, and its relationship to membrane palmitoylated protein 6 (MPP6) and cell adhesion molecule 4 (CADM4), which is analogous to a molecular complex in the erythrocyte membrane skeleton, 4.1R–MPP1–glycophorin C. In 4.1G-deficient nerve fibers, the height of the SLI-truncated cones was reduced compared to that in the wild type. 4.1G was essential for molecular targeting of MPP6 and CADM4 in SLI. Second, we discuss a signal transduction protein, Src, in the SLIs of mouse sciatic nerves, and its phosphorylation states under normal conditions or deletion of 4.1G. Normally, Src is phosphorylated in Y527, but not in Y418. Developmentally, the phosphorylation in Y418 appeared in SLIs of early postnatal mouse sciatic nerves. An MPP6–Src interaction was found, and the phosphorylation of Y418 appeared in 4.1G-deficient nerve fibers. The functional meaning of the Src localization in SLI is discussed. Here, we demonstrate a novel Src–MPP6–4.1G–CADM4 membrane skeletal molecular complex in SLIs, with potential roles in regulation of adhesion and signal transduction in Schwann cells.

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Authors and Affiliations

  1. Department of Occupational Therapy, School of Health Sciences, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan

    Nobuo Terada

  2. Department of Anatomy and Molecular Histology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo City, Yamanashi, Japan

    Nobuo Terada, Yurika Saitoh, Nobuhiko Ohno & Shinichi Ohno

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  1. Nobuo Terada
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  2. Yurika Saitoh
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  3. Nobuhiko Ohno
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  4. Shinichi Ohno
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Correspondence to Nobuo Terada .

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  1. Department of Sensory and Motor Systems, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan

    Kazunori Sango

  2. Department of Pharmacology, National Research Institute for Child Health and Development, Tokyo, Japan

    Junji Yamauchi

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Terada, N., Saitoh, Y., Ohno, N., Ohno, S. (2014). Membrane Skeleton in Schmidt–Lanterman Incisure in Schwann Cells of the Peripheral Nervous System. In: Sango, K., Yamauchi, J. (eds) Schwann Cell Development and Pathology. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54764-8_3

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