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Deciphering Cerebellar Neural Circuitry Involved in Higher Order Functions Using the Zebrafish Model

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New Principles in Developmental Processes

Abstract

The central nervous system (CNS) in vertebrate species is one of the most complex structures in the animal body, containing enormous numbers of neurons that connect to each other through their axons and dendrites to carry out complex tasks. Recent comparative anatomical and functional studies of neural circuits in different vertebrate CNS reveal that, although the structure of the CNS is simpler in lower vertebrates (such as teleosts) than that in mammals, the basic organization of neural circuitry in the CNS is conserved and the formation of neural circuits is controlled by similar or identical mechanisms. In this chapter, we focus on the cerebellum, which is derived from the dorsal part of the most anterior hindbrain and is involved in motor control and higher cognitive/emotional functions. We describe the structure and development processes of the cerebellar neurons and neural circuits in zebrafish and compared them with those in mammals. A variety of techniques and resources is available for zebrafish research on neural development and function, including classical reverse genetics, transgenics, and optogenetics. We discuss how studies on neural circuitry in zebrafish provide us with a general scheme of the formation and function of cerebellar neural circuitry in vertebrate species.

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Acknowledgments

The authors thank past and current members of the Hibi Laboratory for their contribution to the works cited here. The studies conducted in the Hibi Laboratory have been supported by grants from the Uehara Memorial Foundation (M.H.), Takeda Science Foundation (M.H.), the Naito Foundation Natural Science Scholarship (M.H.), and Grants-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Technology (M.H., T.S.)

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  1. Laboratory of Organogenesis and Organ Function, Bioscience and Biotechnology Center, Nagoya University, Furo, Chikusa, Nagoya, Japan

    Masahiko Hibi & Takashi Shimizu

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  1. Masahiko Hibi
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  2. Takashi Shimizu
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Correspondence to Masahiko Hibi .

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  1. Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan

    Hisato Kondoh

  2. Graduate School Science, Nagoya University, Nagoya, Japan

    Atsushi Kuroiwa

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Hibi, M., Shimizu, T. (2014). Deciphering Cerebellar Neural Circuitry Involved in Higher Order Functions Using the Zebrafish Model. In: Kondoh, H., Kuroiwa, A. (eds) New Principles in Developmental Processes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54634-4_13

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