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Development of Vaccines Using SeV Vectors Against AIDS and Other Infectious Diseases

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Sendai Virus Vector

Abstract

Development of effective vaccines, essential for the control of a variety of infectious diseases, requires optimization of antigens and delivery systems. Sendai virus (SeV) vector has been recognized as a promising, novel vaccine delivery tool. We have shown the potential of a recombinant SeV vector vaccine to efficiently induce antigen-specific cytotoxic T-lymphocyte (CTL) responses, leading to control of viral replication in a macaque AIDS model. An international collaborative project toward a clinical trial of an AIDS vaccine using SeV vectors is now proceeding. This vector with the potential to efficiently induce CTL as well as antibody responses would be useful for vaccines against a large variety of infectious diseases.

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  1. AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan

    Sayuri Seki & Tetsuro Matano

  2. The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan

    Sayuri Seki & Tetsuro Matano

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  1. CRNID, RIKEN, Tokyo, Tokyo, Japan

    Yoshiyuki Nagai

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Seki, S., Matano, T. (2013). Development of Vaccines Using SeV Vectors Against AIDS and Other Infectious Diseases. In: Nagai, Y. (eds) Sendai Virus Vector. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54556-9_5

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