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Sendai Virus Biology and Engineering Leading up to the Development of a Novel Class of Expression Vector

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Sendai Virus Vector

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Abstract

Sendai virus (SeV), a prototypic member of the family Paramyxoviridae, was discovered in 1953, six decades ago. It is not just an old mouse pathogen but has been an irreplaceable model in in basic research to understand paramyxovirus replication and pathogenesis. The SeV reverse genetics established in 1996 has played a particularly prominent role in this context by settling outstanding issues and resolving enigmas. At the same time, the technology is evolving into a multipurpose cytoplasmic (nonintegrating) RNA vector. Its diverse medical applications are now in the pipeline and being tested in clinical settings as illustrated in the subsequent chapters. The production of diverse target-oriented devices has been possible by making full use of a variety of SeV theories and traits discovered during the six decades. Here, we summarize the long journey of SeV research leading up to the invention of this novel class of expression vector, SeV vector.

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Authors and Affiliations

  1. RIKEN Center of Research Network for Infectious Diseases, Jimbocho 101 Bldg. 8F, Kandajimbo-cho 1-101, Chiyoda-ku, Tokyo, 101-0051, Japan

    Yoshiyuki Nagai

  2. Division of Radiological Protection & Biology and Division of Quality Assurance, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjyuku-ku, Tokyo, 162-8640, Japan

    Atsushi Kato

Authors
  1. Yoshiyuki Nagai
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  2. Atsushi Kato
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Correspondence to Yoshiyuki Nagai .

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  1. CRNID, RIKEN, Tokyo, Tokyo, Japan

    Yoshiyuki Nagai

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Nagai, Y., Kato, A. (2013). Sendai Virus Biology and Engineering Leading up to the Development of a Novel Class of Expression Vector. In: Nagai, Y. (eds) Sendai Virus Vector. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54556-9_2

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