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Reverse Genetics of Mononegavirales: The Rabies Virus Paradigm

  • Karl-Klaus Conzelmann
Chapter

Abstract

The neurotropic rabies virus (RABV) is a prototype member of the Mononegavirales order of viruses and is the most significant human pathogen of the Rhabdoviridae family. A reverse genetics system for RABV was established almost 20 years ago, providing a paradigm for other Mononegavirales members as well. The availability of engineered recombinant viruses opened a new era to study common aspects of Mononegavirales biology and specific aspects of the unique lifestyle and pathogenesis of individual members. Above all, the knowledge gained has allowed engineering of beneficial biomedical tools such as viral vectors, vaccines, and tracers. In this chapter, the development of the classical rabies virus reverse genetics approach is described, and some of the most exciting biomedical applications for recombinant RABV and other Mononegavirales are briefly addressed.

Keywords

Newcastle Disease Virus Rabies Virus Vesicular Stomatitis Virus Reverse Genetic Hepatitis Delta Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Research in the author’s laboratory is funded by the German Research Foundation (DFG) through SFB 870 and Grako 1202, and the German Federal Ministry of Education and Research (BMBF) grant no. 01KI1016B. I thank Kerstin Schuhmann and Yoshiyuki Nagai for valuable comments on the manuscript.

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© Springer Japan 2013

Authors and Affiliations

  1. 1.Max von Pettenkofer-Institute and Gene CenterLudwig-Maximilians-University MunichMuenchenGermany

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