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Genetic Risk Factors for Neurodegenerative Diseases

  • Chapter
Neurodegenerative Disorders as Systemic Diseases

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Abstract

The contribution of a single gene to each neurodegenerative disease is diverse in its effect size, depth, and mode of action. In those relatively rare neurodegenerative diseases that show a Mendelian pattern of inheritance, mutations in a major causative gene are solely responsible for the disease phenotype and underlying pathogenesis; whereas, the occurrence of more common neurodegenerative diseases likely requires the combined effect of alterations in many genetic factors and independent environmental factors. The pathological process of neuronal degeneration stems from deficits in neuronal or non-neuronal genes. Therefore, understanding the genetic landscape of neurodegeneration requires delineation of the general or unique effect of individual disease-related genes on the neurodegeneration process. Additionally, the interaction among genes should be determined. This chapter overviews, from distinct aspects, representative examples of genetic factors that have a major impact on the pathophysiology of neurodegenerative diseases.

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  1. Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan

    Ken Inoue

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  1. National Center of Neurology and Psychiatry, Kodaira, Japan

    Keiji Wada

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Inoue, K. (2015). Genetic Risk Factors for Neurodegenerative Diseases. In: Wada, K. (eds) Neurodegenerative Disorders as Systemic Diseases. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54541-5_6

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