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The Optic Edge and Adhesive Property of an Intraocular Lens Influences Lens Epithelial Cell Migration Under the Optic

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Cataract Surgery: Maximizing Outcomes Through Research

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Abstract

Purpose: To reveal the factors which influence the inhibitory effect of intraocular lens (IOL) on migration of lens epithelial cells (LECs).

Methods: Porcine LECs were cultured in a cell culture chamber insert, containing a collagen membrane, with IOL optics fixed by the stainless weight. To examine the extent of blocking of LEC migration by the edges of the IOL optics, we measured and summed the angles at the center of the optic that subtended margin portions where LECs had not migrated. The ratio of the sum of these angles to the angle of the entire circumference (360°) was taken as a measure of blocking ability. To examine the LEC migration under IOL optic, the area into which LECs had migrated after removing the weight was measured. Adhesion between the collagen membrane and the IOL optic was measured directly with a tensiometer.

Results: The blocking ability was affected by the type of the IOL (P = 0.0001). The blocking abilities of acrylic and silicone IOL with sharp edge were significantly higher than that of acrylic IOL with rounded edge (P = 0.0015, P < 0.0001, respectively). There was no difference in the blocking ability between acrylic and silicone IOL with sharp edge (P = 0.2056). After weight removal, LECs migrated to various extents on the collagen membrane under IOL optic. The ratio of cell-migrated area (migration ratio) ranged from 3.1 ± 3.2 % for acrylic IOL to 17.1 ± 4.0 % for PMMA IOL. A significant difference in maximum tensions was evident between IOL optics (P = 0.0060). The migration ratio was negatively related to maximum tension (P = 0.0476).

Conclusion: These findings suggested that the blocking ability of IOL optic is dependent on the shape of the edge, but not on the optic material. However, LEC migration under IOL optic was affected by the optic material.

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Authors and Affiliations

  1. Department of Ophthalmology, Iwate Medical University School of Medicine, 19-1, Uchimaru, Morioka, Iwate, 020-8505, Japan

    Daijiro Kurosaka M.D.

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  1. Daijiro Kurosaka M.D.
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Correspondence to Daijiro Kurosaka M.D. .

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Editors and Affiliations

  1. Department of Ophthalmology, Tokyo Dental College Suidobashi Hospital, Tokyo, Japan

    Hiroko Bissen-Miyajima

  2. Department of Ophthalmology, Baylor College of Medicine, Houston, TX, USA

    Douglas Donald Koch

  3. Department of Ophthalmology, Baylor College of Medicine, Houston, TX, USA

    Mitchell Patrick Weikert

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Kurosaka, D. (2014). The Optic Edge and Adhesive Property of an Intraocular Lens Influences Lens Epithelial Cell Migration Under the Optic. In: Bissen-Miyajima, H., Koch, D., Weikert, M. (eds) Cataract Surgery: Maximizing Outcomes Through Research. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54538-5_11

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  • DOI: https://doi.org/10.1007/978-4-431-54538-5_11

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