Abstract
To assess the influence of the Fåhraeus–Lindqvist effect on the microcirculation in the microvascular network of the human retina, a mathematical model was used to simulate the arteriovenous distributions of hemodynamic parameters within a dichotomously branching network. The distributions of vascular resistance and wall shear stress as a function of vessel diameter within the retinal microcirculatory network with the Fåhraeus–Lindqvist effect are lower than those without the Fåhraeus–Lindqvist effect. The efficiency of blood transport in the microcirculatory network is 44 % greater with the Fåhraeus–Lindqvist effect than without the Fåhraeus–Lindqvist effect. Thus, the Fåhraeus–Lindqvist effect induced by the non-Newtonian fluid behavior of blood with a red blood cell suspension is effective for reducing in the physical energy required for blood to flow through the microcirculatory network. The wall shear stress and the circumferential wall stress in response to changes in intravascular pressure may be interactively regulated to maintain their individual set points through alterations in the inner radius and wall thickness of vessels.
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Takahashi, T. (2014). The Fåhraeus–Lindqvist Effect on the Retinal Microcirculation. In: Microcirculation in Fractal Branching Networks. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54508-8_4
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DOI: https://doi.org/10.1007/978-4-431-54508-8_4
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