Abstract
As a novel approach for spinal cord regeneration, we focused on the close interaction between the nervous system and blood vessels described as “vascular niche.” In our studies, endothelial progenitor cells (EPCs) or cell populations containing EPCs were used for treating spinal cord injury (SCI) in anticipation of causing the formation of vascular niche. Here we introduce the outcomes of following studies: (1) kinetics of endogenous EPCs in SCI, (2) transplantation of Jagged1 deficit EPCs, and (3) transplantation of human CD133+ cells. Bone marrow transplantation (BMT) from Tie2/lacZ transgenic mice into wild-type mice with SCI showed the recruitment of endogenous EPCs from bone marrow into injured spinal cord and the participation of recruited EPCs in angiogenesis and astrogliosis following SCI. Transplantation of EPCs derived from Jagged1 knockout mice revealed the contribution of transplanted EPCs to the enhancement of astrogliosis through Jagged1-Notch signaling. Human cord blood CD133+ cells and ex vivo expanded CD133+ cells promoted functional recovery after SCI.
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Conflict of Interest Naosuke Kamei declares that he has no conflict of interest.
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Kamei, N. (2014). Vascular Regeneration Therapies for Spinal Cord Injury. In: Uchida, K., Nakamura, M., Ozawa, H., Katoh, S., Toyama, Y. (eds) Neuroprotection and Regeneration of the Spinal Cord. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54502-6_24
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DOI: https://doi.org/10.1007/978-4-431-54502-6_24
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