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Neuroprotection and Regeneration of the Spinal Cord pp 247–253Cite as

Transplantation of Neural Stem Cells with Valproate for Spinal Cord Injury

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Abstract

The regenerative capacity of an injured spinal cord is limited, and once paralysis occurs, it is difficult to improve the situation. We have developed a treatment method called the HINT method (HDAC Inhibitor and Neural stem cell Transplantation) that improves hind limb motor functionality in mice with severe spinal cord injuries by using a combination of antiepileptic drugs and neural stem cells. This chapter will introduce you to the new neural damage reconstruction mechanism employed in the HINT method.

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Conflict of Interest  The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Orthopedic Surgery, Kagoshima Graduate School of Medical and Dental Science, Kagoshima, Japan

    Masahiko Abematsu

  2. The Near-Future Locomotor Organ Medicine Creation Course (Kusunoki Kai), Kagoshima Graduate School of Medical and Dental Science, Kagoshima, Japan

    Masahiko Abematsu

  3. Stem Cell Biology and Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Kinichi Nakashima

Authors
  1. Masahiko Abematsu
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  2. Kinichi Nakashima
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Corresponding author

Correspondence to Masahiko Abematsu .

Editor information

Editors and Affiliations

  1. Dept of Orthop & Rehabilit Med, University of Fukui Faculty of Medical Sciences, Yoshida-gun, Fukui, Japan

    Kenzo Uchida

  2. Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Tokyo, Japan

    Masaya Nakamura

  3. Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

    Hiroshi Ozawa

  4. Department of Orthopedic Surgery, Faculty of Medicine The University of Tokushima, Tokushima, Tokushima, Japan

    Shinsuke Katoh

  5. Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Tokyo, Japan

    Yoshiaki Toyama

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© 2014 Springer Japan

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Abematsu, M., Nakashima, K. (2014). Transplantation of Neural Stem Cells with Valproate for Spinal Cord Injury. In: Uchida, K., Nakamura, M., Ozawa, H., Katoh, S., Toyama, Y. (eds) Neuroprotection and Regeneration of the Spinal Cord. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54502-6_20

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  • DOI: https://doi.org/10.1007/978-4-431-54502-6_20

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  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-54501-9

  • Online ISBN: 978-4-431-54502-6

  • eBook Packages: MedicineMedicine (R0)

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