Abstract
To prove the efficacy of granulocyte colony-stimulating factor (G-CSF) for spinal cord injury (SCI), we performed several animal experiments in rodent SCI models. Through those experiments, we showed G-CSF’s mechanisms of action for SCI.
G-CSF showed efficacy for SCI through mobilization of bone marrow-derived cells. G-CSF attenuated neuronal cell death in vitro and in vivo, resulting in promotion of functional recovery after SCI. Expression of IL-1β and TNF-α was significantly suppressed by G-CSF in the acute phase of SCI. G-CSF promoted upregulation of anti-apoptotic protein Bcl-Xl on oligodendrocytes and suppressed apoptosis of oligodendrocytes after SCI. G-CSF exerted neuroprotective effects via promotion of angiogenesis after SCI.
G-CSF’s current use in the clinic for hematopoietic stimulation and its ongoing clinical trial for brain infarction make it an appealing molecule that could be rapidly placed into trials for acute SCI patients. G-CSF is one of the hopeful candidates for clinical application.
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Masao Koda declares that he has no conflict of interest.
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Koda, M. et al. (2014). Granulocyte Colony-Stimulating Factor-Mediated Neuroprotective Therapy for Spinal Cord Injury. In: Uchida, K., Nakamura, M., Ozawa, H., Katoh, S., Toyama, Y. (eds) Neuroprotection and Regeneration of the Spinal Cord. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54502-6_13
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DOI: https://doi.org/10.1007/978-4-431-54502-6_13
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