Emerging Roles of Heparan Sulfate in Axon Guidance Signaling

  • Masayuki Masu


Accurate wiring of the neural network is a fundamental for higher brain functions. In the developing brain, growing axons are navigated towards their targets by the concerted actions of chemoattractants and chemorepellents. Recent studies have revealed that heparan sulfate, a glycosaminoglycan sugar chain attached to core proteins in proteoglycans, plays pivotal roles in regulating axon guidance signaling. Here some of the topics related to heparan sulfate in axon guidance are reviewed with emphasis on its structure and activity in relation to its synthesizing and modifying enzymes.


Autism Spectrum Disorder Heparan Sulfate Axon Guidance Sugar Chain Heparan Sulfate Chain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Bone morphogenetic protein


Deleted in colorectal cancer


Fibroblast growth factor


Glial cell line-derived neurotrophic factor


Glucuronic acid




Heparin-binding epidermal growth factor


Hepatocyte growth factor


Heparan sulfate


Heparan sulfate proteoglycans


Iduronic acid


Sonic hedgehog


Transforming growth factor-β


Vascular endothelial growth factor


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Copyright information

© Springer Japan 2013

Authors and Affiliations

  1. 1.Department of Molecular NeurobiologyUniversity of TsukubaTsukubaJapan

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