The Role of the Transcription Factor Pax6 in Brain Development and Evolution: Evidence and Hypothesis

  • Noriko Osumi
  • Takako Kikkawa


During mammalian corticogenesis, the dorsal telencephalon is patterned through secreted molecules and transcription factors. Expression of the transcription factor Pax6 demarcates the dorsal telencephalon, thereby patterning the future cortical primordium. Pax6 is also crucial in neurogenesis in the developing cortex through its role in balancing proliferation and differentiation of neural progenitor cells (NPCs). In this chapter, we address the role of Pax6 and its downstream molecules in cortical development and evolution. We also note the possible involvement of Pax6 in the onset of neurodevelopmental diseases.


Ventricular Zone Radial Glia PAX6 Gene Pax6 Expression Radial Glia Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We thank Dr. Yuji Tsunekawa and Mr. Nobuyuki Sakayori for kindly providing their immunohistochemical data. This work was supported by a grant-in-aid for Scientific Research on Priority Areas “Molecular Brain Science” and “Corticogenesis” (to N. O.) from MEXT Japan. T.K. was supported by a Research Fellowship of the Japan Society for the Promotion of Science for Young Scientists.


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Copyright information

© Springer Japan 2013

Authors and Affiliations

  1. 1.Division of Developmental Neuroscience, United Centers for Advanced Research and Translational Medicine (ART), Graduate School of MedicineTohoku UniversitySendaiJapan

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