Genomic Imprinting in the Mammalian Brain



Genomic imprinting has been primarily studied in the context of embryonic growth and development. However, over the past several years new insights into the roles of imprinted genes in the brain have emerged. Using a novel approach based on next-generation sequencing we recently uncovered hundreds of genes exhibiting complex imprinting effects in the brain, including imprinting effects that are brain region specific, developmental stage specific, and sex specific. Here, we provide a historical perspective on genomic imprinting to introduce this exciting area to the neuroscience field. Further, we comment on emerging concepts related to imprinting in the brain revealed by next-generation sequencing. This work suggests a major frontier exists to understand the functional roles of imprinted genes in the regulation of brain development, function, and behavior.


Imprint Gene Preoptic Area Angelman Syndrome Paternal Allele Maternal Allele 
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© Springer Japan 2013

Authors and Affiliations

  1. 1.Department of Neurobiology and Anatomy and Human Genetics, School of MedicineUniversity of UtahEast Salt Lake CityUSA

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