LD for Pancreas Transplantation

  • Takashi Kenmochi
  • Takehide Asano
  • Taihei Ito


The first extrarenal organ to be successfully transplanted using living donors was the pancreas. The first pancreas transplantation using a living donor (LDP) was performed on June 20, 1979, at the University of Minnesota [1, 2]. Furthermore, successful simultaneous pancreas and kidney transplantation from a living donor (LDSPK) was started in 1994 also at the University of Minnesota [3]. The outcome of LDPs performed at the University of Minnesota demonstrated that the segmental pancreas was able to normalize plasma glucose levels and realize an insulin independency in the severe diabetic patients. The outcome of the donors was considered to be acceptable when using the stringent donor criteria concerning the endocrine function [4].

Based on a severe shortage of the deceased donors in our country and the satisfactory outcome of LDPs at the University of Minnesota, we have firstly introduced LDP (LDSPK) in our country on January 7, 2004 [5]. Eighteen LDPs (16 LDSPKs) have, so far, been performed in Chiba-East National Hospital. From 2007, we have introduced LDSPK from ABO-incompatible living donors according to our successful desensitization and immunosuppression protocol for ABO-incompatible kidney transplantation and performed, so far, six cases.

In this chapter, we describe the criteria for living donation, historical background, and the prognosis for living donor from our clinical experiences of sixteen LDSPKs.


Oral Glucose Tolerance Test Distal Pancreatectomy Living Donor Deceased Donor Insulinogenic Index 
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  1. 1.
    Sutherland DER. Pancreas and islet transplantation. II. Clinical trials. Diabetologia. 1981;20:435–50.PubMedCrossRefGoogle Scholar
  2. 2.
    Sutherland DER, Goetz FC, Najarian JS. Living-related donor segmental pancreatectomy for transplantation. Transplant Proc. 1980;12:19–25.PubMedGoogle Scholar
  3. 3.
    Gruessner RWG, Sutherland DER. Simultaneous kidney and segmental pancreas transplants from living related donors: the first two successful cases. Transplantation. 1996;61:1265–8.PubMedCrossRefGoogle Scholar
  4. 4.
    Gruessner RWG, Kendall DM, Drangstveit MB, Gruessner AC, Sutherland DER. Simultaneous pancreas-kidney transplantation from living donors. Ann Surg. 1997;226:471–82.PubMedCentralPubMedCrossRefGoogle Scholar
  5. 5.
    Kenmochi T, Asano T, Maruyama M, Saigo K, Akutsu N, Iwashita C, Ohtsuki K, Suzuki A, Miyazaki M. Living donor pancreas transplantation in Japan. J Hepatobiliary Pancreat Surg. 2010;17(2):101–7.CrossRefGoogle Scholar
  6. 6.
    Tokuyama Y, Sakurai K, Yagui K, Hashimoto N, Saito Y, Kanatsuka A. Pathophysiologic phenotypes of Japanese subjects with varying degrees of glucose tolerance: using the combination of C-peptide secretion rate and minimal model analysis. Metabolism. 2001;50:812–8.PubMedCrossRefGoogle Scholar
  7. 7.
    Otsuki K, Yoshikawa T, Kenmochi T, Maruyama M, Akutsu N, Iwashita C, Ito T, Asano T. Evaluation of segmental pancreatic function using 11C-methionine positron emission tomography for safe living donor operation of pancreas transplantation. Transplant Proc. 2011;43(9):3237–76.CrossRefGoogle Scholar
  8. 8.
    The Japan Society for Transplantation.
  9. 9.
    Gruessner RWG, Sutherland DER, Drangstveit MB, Bland BJ, Gruessner AC. Pancreas transplants from living donors: short- and long term outcome. Transplant Proc. 2001;33:819–20.PubMedCrossRefGoogle Scholar
  10. 10.
    Sutherland DER, Gruessner R, Dunn D, Moudry-Munns K, Gruessner A, Najarian JS. Pancreas transplants from living-related donors. Transplant Proc. 1994;26(2):443–5.PubMedGoogle Scholar
  11. 11.
    Kenmochi T, Asano T, Saigo K, Maruyama M, Akutsu N, Iwashita C, et al. The first case of simultaneous pancreas-kidney transplant from living donor in our country. Jpn J Transplant. 2005;40:466–72.Google Scholar
  12. 12.
    Kendall DM, Sutherland DE, Najarian JS, et al. Effects of hemipancreatectomy on insulin secretion and glucagon tolerance in healthy humans. N Engl J Med. 1990;322:898.PubMedCrossRefGoogle Scholar
  13. 13.
    Seaquist ER, Robertson RP. Effects of hemipancreatectomy on pancreatic alpha and β cell function in healthy human donors. J Clin Invest. 1992;89:1761.PubMedCentralPubMedCrossRefGoogle Scholar
  14. 14.
    Seaquist ER, Gruessner RW. Pancreas transplantation: the donor. Selection criteria for donors. In: Gruessner RW, Benedetti E, editors. Living donor organ transplantation. New York: The McGraw-Hill companies Inc.; 2008.Google Scholar
  15. 15.
    Suzuki A, Kenmochi T, et al. Evaluation of quality of life after simultaneous pancreas and kidney transplantation from living donors using short form 36. Transplant Proc. 2008;40(8):2565–7.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Department of Organ Transplant SurgeryFujita Health UniversityToyoake CityJapan
  2. 2.Department of Surgery and Clinical Research CenterChiba-East National HospitalChiba CityJapan

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