Before inclusion of the concept of brain death into law in the mid- to late 1970s, all organ transplantations came from cadaveric donors after cardiac death (DCD), i.e., non-heart-beating donors (NHBDs). However, the introduction of brain-dead donors (BDD, heart-beating donors) led to better outcomes, as transplant organs were perfused with oxygenated blood right until the time for perfusion and cooling with preservation solution at organ procurement. Thus, DCDs were generally no longer utilized, except in Japan.
However, a growing discrepancy between demand for organs and their availability from BDDs led to a reevaluation of the use of DCD, and some transplant centers are now trying to use such donors to expand their potential pool of organs.
KeywordsBrain Death Plasma Glucose Level Warm Ischemia Organ Procurement Ischemia Group
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