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History of Marginal Donors in the World

  • Norihide Fukushima
Chapter

Abstract

Cadaver organ transplantation was started with donation after cardiac death (DCD). As determination of brain death was not established until 1968, the first liver transplant by Starzl et al. [1] in 1963 and the first heart transplant by Barnard [2] in 1967 were performed with DCD donors whose organs were procured under cardiopulmonary support (CPB). After the Harvard ad hoc committee [3] published the Harvard criteria for brain death in June 1968, organ donation from brain-dead persons has become the main current of cadaver organ transplantation. However, in Japan, only uncontrolled DCD kidney transplantation has been done since the 1960s, because brain-dead organ transplantation was not permitted for a long time.

As organ transplantation rapidly increased and organ shortage became more remarkable, DCD have been widely introduced in the clinical practice and the use of organs, especially kidneys, from DCD donors has been reported in multiple series [4] since the late 1980s in the developed countries. At that time, controlled DCD was the main current. Therefore, organs were harvested after cardiac death induced by extubation of the donor.

As percutaneous cardiopulmonary support (PCPS) was introduced in the clinical settings in the late 1980s, uncontrolled DCD using PCPS was initiated in Spain [5]. In 2000, Steen et al. [6] started uncontrolled DCD lung transplantation in Sweden.

Keywords

Organ Transplantation Brain Death Biliary Atresia Donation After Cardiac Death Main Current 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Starzl TE, Marchioro TL, Vonkaulla KN, et al. Homotransplantation of the liver in humans. Surg Gynecol Obstet. 1963;117:659–76.PubMedCentralPubMedGoogle Scholar
  2. 2.
    Barnard CN. The operation — A human cardiac transplant: an interim report of a successful operation performed at Groote Schuur Hospital, Cape Town. S Afr Med J. 1967;41:1271–4.PubMedGoogle Scholar
  3. 3.
    Ad Hoc Committee of the Harvard Medical School. A definition of irreversible coma: report of the Ad Hoc Committee of the Harvard Medical School to examine the definition of brain death. JAMA. 1968;205:337–40.CrossRefGoogle Scholar
  4. 4.
    Abt PL, Desai NM, Crawford MD, et al. Survival following liver transplantation from non-heartbeating donors. Ann Surg. 2004;239:87–92.PubMedCentralPubMedCrossRefGoogle Scholar
  5. 5.
    Valero R, Cabrer C, Oppenhaimer F, et al. Normothermic recirculation reduces primary graft dysfunction of kidneys obtained from non-heart-beating donors. Transpl Int. 2000;13:303–10.PubMedCrossRefGoogle Scholar
  6. 6.
    Steen S, Sjoberg T, Pierre L, et al. Transplantation of lungs from a non-heart-beating donor. Lancet. 2001;357:825–9.PubMedCrossRefGoogle Scholar
  7. 7.
    Matevossian E, Kern H, Hüser N, et al. Surgeon Yurii Voronoy (1895–1961) – a pioneer in the history of clinical transplantation: in memoriam at the 75th anniversary of the first human kidney transplantation. Transpl Int. 2009;22:1132–9.PubMedCrossRefGoogle Scholar
  8. 8.
    Murray JE, Merrill JP, Harrison JH, et al. Prolonged survival of human-kidney homografts by immunosuppressive drug therapy. N Engl J Med. 1963;268:1315–23.PubMedCrossRefGoogle Scholar
  9. 9.
    Stinson EB, Dong Jr E, Schroeder JS, et al. Initial clinical experience with heart transplantation. Am J Cardiol. 1968;22:791–803.PubMedCrossRefGoogle Scholar
  10. 10.
    Squifflet JP. The history of transplantation at the Catholic University of Louvain, Belgium 1963–2003. Acta Chir Belg. 2003;103:10–20.PubMedGoogle Scholar
  11. 11.
    Fukushima N, Ono M, Nakatani T, et al. Strategies for maximizing heart and lung transplantation opportunities in Japan. Transplant Proc. 2009;41:273–6.PubMedCrossRefGoogle Scholar
  12. 12.
    Koyama I, Hoshino T, Nagashima N, Adachi H, Ueda K, Omoto R. A new approach to kidney procurement from non-heart-beating donors: core cooling on cardiopulmonary bypass. Transplant Proc. 1989;21:1203–5.PubMedGoogle Scholar
  13. 13.
    Fukushima N, Shirakura R, Chang JC, et al. Successful experimental multiorgan transplant from non heart beating donors using percutaneous cardiopulmonary support. ASAIO J. 1998;44:M525–8.PubMedCrossRefGoogle Scholar
  14. 14.
    Fondevilaa C, Hessheimera AJ, Ruiz A, et al. Liver transplant using donors after unexpected cardiac death: novel preservation protocol and acceptance criteria. Am J Transpl. 2007;7:1849–55.CrossRefGoogle Scholar
  15. 15.
    Gamez P, Cordoba M, Ussetti P, et al. Lung transplantation from out-of-hospital non-heart-beating lung donors. One-year experience and results. J Heart Lung Transplant. 2005;24:1098–110.PubMedCrossRefGoogle Scholar
  16. 16.
    Snell GI, Levvey BJ, Oto T, et al. Early lung transplantation success utilizing controlled donation after cardiac death donors. Am J Transplant. 2008;8:1282–9.PubMedCrossRefGoogle Scholar
  17. 17.
    Reddy SP, Brockmann J, Friend PJ. Normothermic perfusion: a mini-review. Transplantation. 2009;87:631–2.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Department of Therapeutics for End-Stage Organ DysfunctionOsaka University Graduate School of MedicineSuitaJapan

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