Abstract
The number of reports published on the follow-up data of patients with BD-IPMN has been increasing. Accumulating evidence from independent 12 studies revealed that the mean frequency of morphological changes of BD-IPMN, such as increased cyst size, increased MPD diameter, and/or appearance or enlargement of MNs, was 27.4 % (range, 14.9–61.8 %) of 1,293 followed-up patients (follow-up period, 2.6–8.1 years). Surgical resection was carried out in 9.9 % (range, 0–22.2 %) of all cases. Among the resected cases, 27.3 % were diagnosed histologically as malignant. During the follow-up period, malignant transformation was observed in only 2.7 %. BD-IPMNs without MNs have a low risk for malignant transformation regardless of cyst size at the initial diagnosis. Malignant transformation is associated with signs of progression especially appearance or enlargement of MNs and/or an increase in the MPD diameter. On the other hand, PDAC develops independently in the pancreas distinct from BD-IPMN. The mean frequency of PDAC occurrence was 2.8 % (range, 1.4–8.0 %) of all cases during the follow-up.
In conclusion, careful attention should be paid to the occurrence of PDAC in the entire pancreas in addition to progression of BD-IPMN when performing follow-up examinations in patients with BD-IPMN.
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Maguchi, H., Tanno, S. (2014). Natural History and Malignant Transformation of Branch Duct IPMN. In: Tanaka, M. (eds) Intraductal Papillary Mucinous Neoplasm of the Pancreas. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54472-2_3
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