Skip to main content
SpringerLink
Log in

Postoperative Surveillance of Branch Duct IPMN

  • Chapter
  • First Online:
Book cover Intraductal Papillary Mucinous Neoplasm of the Pancreas

Abstract

Surveillance protocol after resection of branch duct IPMNs (BD-IPMNs) is determined based on the following factors: (1) pathological grade of resected BD-IPMNs, (2) pancreatic margin status after partial pancreatectomy, (3) presence of the residual lesions left without resection in the remnant pancreas, (4) presence of concomitant PDACs at the time of operation, (5) the possibility of metachronous occurrence of BD-IPMNs, and (6) development of concomitant PDACs in the remnant pancreas. Yearly risk of PDAC development is reported to be 0.7–0.9 % in the patients with BD-IPMNs, and thus international consensus guidelines suggest that CT or MRCP at 6-month intervals is appropriate for surveillance after resection of BD-IPMNs, even though the resected IPMN is benign with negative surgical margin. Surveillance with shorter interval should be considered in patients who underwent resection of invasive IPMNs, who had positive surgical margin status, or who have significant clinical signs to suspect the progression or new development of the disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Chari ST, Yadav D, Smyrk TC, et al. Study of recurrence after surgical resection of intraductal papillary mucinous neoplasm of the pancreas. Gastroenterology. 2002;123:1500–7.

    Article  PubMed  Google Scholar 

  • Couvelard A, Sauvanet A, Kainmanesh R, et al. Frozen sectioning of the pancreatic cut surface during resection of intraductal papillary mucinous neoplasms of the pancreas is useful and reliable. Ann Surg. 2005;242:774–80.

    Article  PubMed  Google Scholar 

  • Furukawa T, Hatori T, Fujita I, et al. Prognostic relevance of morphological types of intraductal papillary mucinous neoplasms of the pancreas. Gut. 2011;60:509–16.

    Article  PubMed  Google Scholar 

  • Ideno N, Ohtsuka T, Tamura K, et al. Intraductal papillary mucinous neoplasms of the pancreas with distinct pancreatic ductal adenocarcinomas are frequently of gastric subtype. Ann Surg. 2013;258:141–51.

    Google Scholar 

  • Ingkakul T, Sadakari Y, Ienaga J, et al. Predictors of the presence of concomitant invasive ductal carcinoma in intraductal papillary mucinous neoplasm of the pancreas. Ann Surg. 2010;251:70–5.

    Article  PubMed  Google Scholar 

  • Japan Pancreas Society. Classification of pancreatic carcinoma. 3rd ed. Tokyo: Kanehara; 2011.

    Google Scholar 

  • Kobayashi G, Fujita N, Noda Y, et al. Lateral spread along the main pancreatic duct in branch-duct intraductal papillary-mucinous neoplasms of the pancreas: usefulness of intraductal ultrasonography for its evaluation. Dig Endosc. 2011;23:62–8.

    Article  PubMed  Google Scholar 

  • Maguchi H, Tanno S, Mizuno N, et al. Natural history of branch duct intraductal papillary mucinous neoplasms of the pancreas: a multicenter study in Japan. Pancreas. 2011;40:364–70.

    Article  PubMed  Google Scholar 

  • Matthaei H, Norris AL, Tsiatis AC, et al. Clinicopathological characteristics and molecular analyses of multifocal intraductal papillary mucinous neoplasms of the pancreas. Ann Surg. 2012;255:326–33.

    Article  PubMed  Google Scholar 

  • Mino-Kenudson M, Fernández-del Castillo C, Baba Y, et al. Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypes. Gut. 2011;60:1712–20.

    Article  PubMed  Google Scholar 

  • Mori Y, Ohtsuka T, Kono H, et al. Management strategy for multifocal branch duct intraductal papillary mucinous neoplasms of the pancreas. Pancreas. 2012;41:1008–12.

    Article  PubMed  CAS  Google Scholar 

  • Ohtsuka T, Kono H, Tanabe R, et al. Follow-up study after resection of intraductal papillary mucinous neoplasm of the pancreas; special references to the multifocal lesions and development of ductal carcinoma in the remnant pancreas. Am J Surg. 2012;204:44–8.

    Article  PubMed  Google Scholar 

  • Ohtsuka T, Ideno N, Aso T, et al. Role of endoscopic retrograde pancreatography to detect early pancreatic ductal carcinoma concomitant with intraductal papillary mucinous neoplasm of the pancreas. J Hepatobiliary Pancreat Sci. 2013;20:356–61.

    Article  PubMed  Google Scholar 

  • Okada K, Imaizumi T, Hirabayashi K, et al. The distance of the tumor spread in the main pancreatic duct of an intraductal papillary-mucinous neoplasm: where to resect and how to predict it. J Hepatobiliary Pancreat Sci. 2010;17:516–22.

    Article  PubMed  Google Scholar 

  • Partelli S, Fernández-del Castillo C, Bassi C, et al. Invasive intraductal papillary mucinous carcinomas of the pancreas. Predictors of survival and the role of lymph node ratio. Ann Surg. 2010;251:477–82.

    Article  PubMed  Google Scholar 

  • Poultsides GA, Reddy S, Cameron JL, et al. Histopathologic basis for the favorable survival after resection of intraductal papillary mucinous neoplasm-associated invasive adenocarcinoma of the pancreas. Ann Surg. 2010;251:470–6.

    Article  PubMed  Google Scholar 

  • Reid-Lombardo KM, Mathis KL, Wood CM, et al. Frequency of extrapancreatic neoplasms in intraductal papillary mucinous neoplasm of the pancreas. Implication for management. Ann Surg. 2010;251:64–9.

    Article  PubMed  Google Scholar 

  • Rodriguez JR, Salvia R, Crippa S, et al. Branch-duct intraductal papillary mucinous neoplasms: observations in 145 patients who underwent resection. Gastroenterology. 2007;133:72–9.

    Article  PubMed  Google Scholar 

  • Sadakari Y, Ohuchida K, Nakata K, et al. Invasive carcinoma derived from non-intestinal type intraductal papillary mucinous neoplasm of the pancreas has a poorer prognosis than that derived from intestinal type. Surgery. 2010;147:812–7.

    Article  PubMed  Google Scholar 

  • Salvia R, Fernández-del Castillo C, Bassi C, et al. Main-duct intraductal papillary mucinous neoplasms of the pancreas. Clinical predictors of malignancy and long-term survival following resection. Ann Surg. 2004;239:678–87.

    Article  PubMed  Google Scholar 

  • Sawai Y, Yamao K, Bhatia V, et al. Development of pancreatic cancers during long-term follow-up of side-branch intraductal papillary mucinous neoplasms. Endoscopy. 2010;42:1077–84.

    Article  PubMed  CAS  Google Scholar 

  • Sohn TA, Yeo CJ, Cameron JL, et al. Intraductal papillary mucinous neoplasms of the pancreas. An updated experience. Ann Surg. 2004;239:788–99.

    Article  PubMed  Google Scholar 

  • Sugiyama M, Atomi Y. Extrapancreatic neoplasms occur with unusual frequency in patients with intraductal papillary mucinous tumors of the pancreas. Am J Gastroenterol. 1999;94:470–3.

    Article  PubMed  CAS  Google Scholar 

  • Tada M, Kawabe T, Arizumi M, et al. Pancreatic cancer in patients with pancreatic cystic lesions: a prospective study in 197 patients. Clin Gastroenterol Hepatol. 2006;4:1265–70.

    Article  PubMed  Google Scholar 

  • Tanaka M, Fernández-del Castillo C, Adsay V, et al. International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology. 2012;12:183–97.

    Article  PubMed  Google Scholar 

  • Tanno S, Nakano Y, Koizumi K, et al. Pancreatic ductal adenocarcinomas in long-term follow-up patients with branch duct intraductal papillary mucinous neoplasms. Pancreas. 2010a;39:36–40.

    Article  PubMed  Google Scholar 

  • Tanno S, Nakano Y, Sugiyama Y, et al. Incidence of synchronous and metachronous pancreatic carcinoma in 168 patients with branch duct intraductal papillary mucinous neoplasms. Pancreatology. 2010b;10:173–8.

    Article  PubMed  Google Scholar 

  • Uehara H, Nakaizumi A, Ishikawa O, et al. Development of ductal carcinoma of the pancreas during follow-up of branch duct intraductal papillary mucinous neoplasms of the pancreas. Gut. 2008;57:1561–5.

    Article  PubMed  CAS  Google Scholar 

  • Wada K, Kozarek RA, Traverso LW. Outcomes following resection of invasive and noninvasive intraductal papillary mucinous neoplasms of the pancreas. Am J Surg. 2005;189:632–7.

    Article  PubMed  Google Scholar 

  • White R, D’Angelica M, Katabi N, et al. Fate of the remnant pancreas after resection of noninvasive intraductal papillary mucinous neoplasm. J Am Coll Surg. 2007;204:987–95.

    Article  PubMed  Google Scholar 

  • Yamaguchi K, Ohuchida J, Ohtsuka T, et al. Intraductal papillary-mucinous tumor of the pancreas concomitant with ductal carcinoma of the pancreas. Pancreatology. 2002;2:484–90.

    Article  PubMed  Google Scholar 

  • Yamaguchi K, Kanemitsu S, Hatori T, et al. Pancreatic ductal adenocarcinoma derived from IPMN and pancreatic ductal adenocarcinoma concomitant with IPMN. Pancreas. 2011;40:571–80.

    Article  PubMed  Google Scholar 

  • Yopp AC, Katabi N, Janakos M, et al. Invasive carcinoma arising in intraductal papillary mucinous neoplasms of the pancreas. A match control study with conventional pancreatic ductal adenocarcinoma. Ann Surg. 2011;253:968–74.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Takao Ohtsuka & Masao Tanaka

Authors
  1. Takao Ohtsuka
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Masao Tanaka
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Takao Ohtsuka .

Editor information

Editors and Affiliations

  1. Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan

    Masao Tanaka

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Japan

About this chapter

Cite this chapter

Ohtsuka, T., Tanaka, M. (2014). Postoperative Surveillance of Branch Duct IPMN. In: Tanaka, M. (eds) Intraductal Papillary Mucinous Neoplasm of the Pancreas. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54472-2_16

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-54472-2_16

  • Published:

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-54471-5

  • Online ISBN: 978-4-431-54472-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation