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RFA of Breast Cancer: Technique2, Knack and Pitfall

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Non-surgical Ablation Therapy for Early-stage Breast Cancer
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Abstract

Approval for this study was obtained from our institutional ethics committee, and written informed consent was obtained from each patient prior to the procedure. Patients were admitted to the hospital the day before RF ablation treatment. Preablation imaging workup included mammography, an unenhanced and a contrast-enhanced US 11)12), and MRI of the breast.

Contrast-enhanced US using Sonazoid® with a median microbubble diameter of 2–3 μm was done for detection of breast tumor lesion and extensive intraductal component.

The skin entry site of electrode that allowed path of maximum tumor diameter plane was chosen. The device induces an ablation sphere of 3–4 cm in diameter. Because the maximum size of the target tumors was 2.0 cm in diameter, the ablation protocol was planned with the aim to destroy the visible tumor mass plus at least a 0.5-cm safety margin around the tumor. Five percent glucose solution was injected into the retromammary space to avoid burns of the major pectoral muscle. The skin just above the tumor was cooled with an ice pack.

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References

  1. Singletary S,E. Minimally invasive surgery in breast cancer treatment. Biomed Pharmacother. 2001;55:510–4.

    Article  CAS  PubMed  Google Scholar 

  2. Oura S, Tamaki T, Hirai I, et al. Radiofrequency ablation therapy in patients with breast cancers two centimeters or less in size. Breast Cancer. 2007;14(1):48–54.

    Article  PubMed  Google Scholar 

  3. Yamamoto N, Fujimoto H, Nakamura R, et al. Pilot study of radiofrequency ablation therapy without surgical excision for T1 breast cancer: evaluation with MRI and vacuum-assisted core needle biopsy and safety management. Breast Cancer. 2011;18(1):3–9.

    Article  PubMed  Google Scholar 

  4. Khatri VP, McGahan JP, Ramsamooj R, et al. A phase II trial of image-guided radiofrequency ablation of small invasive breast carcinomas: use of saline-cooled tip electrode. Ann Surg Oncol. 2007;14(5):1644–52.

    Article  PubMed  Google Scholar 

  5. Medina-Franco H, Sato-Germes S, Ulloa-Gomez JL, et al. Radiofrequency ablation of invasive breast carcinomas: a phase II trial. Ann Surg Oncol. 2008;15:1689–95.

    Article  PubMed  Google Scholar 

  6. Manenti G, Bolacchi F, Perretta T, et al. Small breast cancers: in vivo percutaneous US-guided radiofrequency ablation with dedicated cool-tip radiofrequency system. Radiology. 2009;251:339–46.

    Article  PubMed  Google Scholar 

  7. Garbay J-R, Mathieu M-C, Lamuraglia M, et al. Radiofrequency thermal ablation of breast cancer local recurrence: a phase II clinical trial. Ann Surg Oncol. 2008;15:3222–6.

    Article  PubMed  Google Scholar 

  8. Fornage BD, Sneige N, Ross MI. Small (<2-cm) breast cancer treated with US-guided radiofrequency ablation: feasibility study. Radiology. 2004;231:215–24.

    Article  PubMed  Google Scholar 

  9. Earashi M, Noguchi M, Motoyoshi A, et al. Radiofrequency ablation therapy for small breast cancer followed by immediate surgical resection or delayed mammotome excision. Breast Cancer. 2007;14:39–47.

    Article  PubMed  Google Scholar 

  10. Nagashima T, Sakakibara M, Sangai T, et al. Surrounding rim formation and reduction in size after radiofrequency ablation for primary breast cancer. Jpn J Radiol. 2009;27:197–204.

    Article  PubMed  Google Scholar 

  11. Miyamoto Y, Ito T, Takada E, Omoto K, et al. PhaseIIclinical study of DD-723 (perflubutane): dose-response study in patients with breast tumors. J Med Ultrasonics. 2012;39:79–86.

    Article  Google Scholar 

  12. Miyamoto Y, Ito T, Takada E, Omoto K et al. Efficacy of SONAZOID® (perflubutane) contrast-enhanced ultrasound in the differentiation of focal breast lesions: phase 3 multicenter clinical trial. AJR. 2014;202(4):W400–7.

    Article  PubMed  Google Scholar 

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Correspondence to Toshikazu Ito .

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Ito, T. (2016). RFA of Breast Cancer: Technique2, Knack and Pitfall. In: Kinoshita, T. (eds) Non-surgical Ablation Therapy for Early-stage Breast Cancer. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54463-0_7

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  • DOI: https://doi.org/10.1007/978-4-431-54463-0_7

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  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-54462-3

  • Online ISBN: 978-4-431-54463-0

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