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RFA of Breast Cancer: Criteria and Procedure

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Non-surgical Ablation Therapy for Early-stage Breast Cancer

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Abstract

Advances in healthcare and screening technologies have led to the detection of smaller tumors and earlier-stage breast cancers. Although breast-conserving surgery is a standard surgical option, it cannot always achieve a satisfactory cosmetic result.

Minimally invasive alternatives to surgery are becoming more attractive for selective patient populations. RFA using a high-frequency alternating current to heat a volume of tissue around a needle electrode to induce focal coagulative necrosis appears to be the most promising method.

Although RFA for early-stage breast cancer has exhibited promising effectiveness and lower morbidity, the role of RFA in primary treatment continues to evolve. RFA is a relatively simple procedure that involves tumor puncture under ultrasound guidance.

This chapter will discuss the general criteria of RFA and outline the steps of the procedure in commonly encountered small breast tumors. The key factors for the successful eradication of cancer cells are tumor size and location in the breast and accurate placement of the needle in the center of the tumor.

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References

  1. Van Esser S, van den Bosch MA, van Diest PJ, et al. Minimally invasive ablative therapies for invasive breast carcinomas: an overview of current literature. World J Surg. 2007;31:2284–92.

    Article  PubMed  Google Scholar 

  2. Schässburger K-U, Löfgren L, Lagerstedt U, et al. Minimally-invasive treatment of early stage breast cancer: a feasibility study using radiofrequency ablation under local anesthesia. Breast. 2014;23:152–8.

    Article  PubMed  Google Scholar 

  3. Wiksell H, Löfgren L, Schässburger K-U, et al. Feasibility study on the treatment of small breast carcinoma using percutaneous US-guided preferential radiofrequency ablation (PRFA). Breast. 2010;19(3):219–25.

    Google Scholar 

  4. Nagashima T, Sakakibara M, Sangai T, et al. Surrounding rim formation and reduction in size after radiofrequency ablation for primary breast cancer. Jpn J Radiol. 2009;27:197–204.

    Article  PubMed  Google Scholar 

  5. Manenti G, Bolacchi F, Perretta T, et al. Small breast cancers: in vivo percutaneous US-guided radiofrequency ablation with dedicated cool-tip radiofrequency system. Radiology. 2009;251:339–46.

    Article  PubMed  Google Scholar 

  6. Hayashi AH, Silver SF, van der Westhuizen NG, et al. Treatment of invasive breast carcinoma with ultrasound-guided radiofrequency ablation. Am J Surg. 2003;185:429–35.

    Article  PubMed  Google Scholar 

  7. Imoto S, Wada N, Sakemura N, et al. Feasibility study on radiofrequency ablation followed by partial mastectomy for stage I breast cancer patients. Breast. 2009;18:130–4.

    Article  PubMed  Google Scholar 

  8. Khatri VP, McGahan JP, Ramsamooj R, et al. A phase II trial of image-guided radiofrequency ablation of small invasive breast carcinomas: use of saline-cooled tip electrode. Ann Surg Oncol. 2007;14:1644–52.

    Article  PubMed  Google Scholar 

  9. Noguchi M. Is radiofrequency ablation treatment for small breast cancer ready for “prime time”? Breast Cancer Res Treat. 2007;106:307–14.

    Article  PubMed  Google Scholar 

  10. Ekstrand V, Wiksell H, Schultz I, et al. Influence of electrical and thermal properties on RF ablation of breast cancer: is the tumour preferentially heated? Biomed Eng Online. 2005;4:41.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Palussière J, Henriques C, Mauriac L, et al. Radiofrequency ablation as a substitute for surgery in elderly patients with nonresected breast cancer: pilot study with long-term outcomes. Radiology. 2012;264:597–605.

    Article  PubMed  Google Scholar 

  12. Fornage BD, Sneige N, Ross MI, et al. Small (< or = 2-cm) breast cancer treated with US-guided radiofrequency ablation: feasibility study. Radiology. 2004;231:215–24.

    Article  PubMed  Google Scholar 

  13. NCCN. NCCN Clinical Practice Guidelines 2014 in Oncology (NCCN Guidelines) Breast Cancer. NCCN.org 2014. http://www.nccn.org/professionals/physician_gls/f_guidelines.asp

  14. Van der Ploeg IMC, van Esser S, van den Bosch MJ, et al. Radiofrequency ablation for breast cancer: a review of the literature. Eur J Surg Oncol. 2007;33:673–7.

    Article  PubMed  Google Scholar 

  15. Zhao Z, Wu F. Minimally-invasive thermal ablation of early-stage breast cancer: a systemic review. Eur J Surg Oncol. 2010;36:1149–55.

    Article  CAS  PubMed  Google Scholar 

  16. Soukup B, Bismohun S, Reefy S, Mokbel K. The evolving role of radiofrequency ablation therapy of breast lesions. Anticancer Res. 2010;30:3693–7.

    CAS  PubMed  Google Scholar 

  17. Earashi M, Noguchi M, Motoyoshi A, Fujii H. Radiofrequency ablation therapy for small breast cancer followed by immediate surgical resection or delayed mammotome excision. Breast Cancer. 2007;14:39–47.

    Article  PubMed  Google Scholar 

  18. Noguchi M, Earashi M, Fujii H, et al. Radiofrequency ablation of small breast cancer followed by surgical resection. J Surg Oncol. 2006;93:120–8.

    Article  PubMed  Google Scholar 

  19. Kinoshita T, Iwamoto E, Tsuda H, Seki K. Radiofrequency ablation as local therapy for early breast carcinomas. Breast Cancer. 2011;18:10–7.

    Article  PubMed  Google Scholar 

  20. Medina-Franco H, Soto-Germes S, Ulloa-Gómez JL, et al. Radiofrequency ablation of invasive breast carcinomas: a phase II trial. Ann Surg Oncol. 2008;15:1689–95.

    Article  PubMed  Google Scholar 

  21. Burak WE, Agnese DM, Povoski SP, et al. Radiofrequency ablation of invasive breast carcinoma followed by delayed surgical excision. Cancer. 2003;98:1369–76.

    Article  PubMed  Google Scholar 

  22. Dodd GD, Frank MS, Aribandi M, et al. Radiofrequency thermal ablation: computer analysis of the size of the thermal injury created by overlapping ablations. AJR Am J Roentgenol. 2001;177:777–82.

    Article  PubMed  Google Scholar 

  23. Susini T, Nori J, Olivieri S, et al. Radiofrequency ablation for minimally invasive treatment of breast carcinoma. A pilot study in elderly inoperable patients. Gynecol Oncol. 2007;104:304–10.

    Article  PubMed  Google Scholar 

  24. Dickson JA, Calderwood SK. Temperature range and selective sensitivity of tumors to hyperthermia: a critical review. Ann N Y Acad Sci. 1980;335:180–205.

    Article  CAS  PubMed  Google Scholar 

  25. Goldberg SN, Gazelle GS, Halpern EF, et al. Radiofrequency tissue ablation: importance of local temperature along the electrode tip exposure in determining lesion shape and size. Acad Radiol. 1996;3:212–8.

    Article  CAS  PubMed  Google Scholar 

  26. Hung WK, Mak KL, Ying M, Chan M. Radiofrequency ablation of breast cancer: a comparative study of two needle designs. Breast Cancer. 2011;18:124–8.

    Article  PubMed  Google Scholar 

  27. Quaranta V, Manenti G, Bolacchi F, et al. FEM analysis of RF breast ablation: multiprobe versus cool-tip electrode. Anticancer Res. 2007;27:775–84.

    CAS  PubMed  Google Scholar 

  28. Grotenhuis BA, Vrijland WW, Klem TMAL. Radiofrequency ablation for early-stage breast cancer: treatment outcomes and practical considerations. Eur J Surg Oncol. 2013;39:1317–24.

    Article  CAS  PubMed  Google Scholar 

  29. Ahmed M, Brace CL, Lee FT, Goldberg SN. Principles of and advances in percutaneous ablation. Radiology. 2011;258:351–69.

    Article  PubMed  Google Scholar 

  30. Leylek AM, Whitman GJ, Vilar VS, et al. Radiofrequency ablation for breast cancer. Tech Vasc Interv Radiol. 2013;16:269–76.

    Article  PubMed  Google Scholar 

  31. Izzo F, Thomas R, Delrio P, et al. Radiofrequency ablation in patients with primary breast carcinoma: a pilot study in 26 patients. Cancer. 2001;92:2036–44.

    Article  CAS  PubMed  Google Scholar 

  32. Vilar VS, Goldman SM, Ricci MD, et al. Analysis by MRI of residual tumor after radiofrequency ablation for early stage breast cancer. AJR Am J Roentgenol. 2012;198:W285–91.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of General and Breast Surgery, Tokyo Dental College Ichikawa General Hospital, 5-11-13 Sugano, 272-8513, Ichikawa, Chiba, Japan

    Noriaki Wada

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  1. Noriaki Wada
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Correspondence to Noriaki Wada .

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Editors and Affiliations

  1. Division of Breast Surgery, National Cancer Center Hospital, Tokyo, Tokyo, Japan

    Takayuki Kinoshita

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Wada, N. (2016). RFA of Breast Cancer: Criteria and Procedure. In: Kinoshita, T. (eds) Non-surgical Ablation Therapy for Early-stage Breast Cancer. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54463-0_5

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  • DOI: https://doi.org/10.1007/978-4-431-54463-0_5

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  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-54462-3

  • Online ISBN: 978-4-431-54463-0

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