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Testicular Autoimmunity pp 65–92Cite as

Human Testicular Autoimmunity as a Result of Breakdown of Testicular Immune Privilege

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Abstract

The BTB physically divides the seminiferous epithelium into basal and adluminal compartments. Besides its function as an immunologic barrier to segregate post-meiotic TGC from the systemic circulation, it creates a microenvironment for TGC development and confers cell polarity (Fig. 3.1). At puberty, when immune competence is already established, TGC commence a new program which leads to the formation of mature spermatozoa. During this process, an array of new surface molecules is expressed on the differentiating spermatids and spermatozoa (Ike et al. 2007). Such autoantigens, therefore, do not belong to the “family” of those considered as “self” by the immune system. Therefore, under some condition in which the testicular immune privilege is broken, immune responses against the testicular autoantigens should be evoked.

The original version of this chapter was revised. An erratum to this chapter can be found at DOI 10.1007/978-4-431-54460-9_9

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  1. Department of Anatomy, Tokyo Medical University, Shinjyuku-ku, Tokyo, Japan

    Masahiro Itoh

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Itoh, M. (2017). Human Testicular Autoimmunity as a Result of Breakdown of Testicular Immune Privilege. In: Testicular Autoimmunity. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54460-9_3

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