Skip to main content
SpringerLink
Log in
Book cover

Carbon-Ion Radiotherapy pp 39–45Cite as

Biophysical Models and RBE

  • Chapter
  • First Online:

Abstract

A primary goal for treatment delivery is to achieve a homogenous effect throughout the target volume. In contrast to conventional photon therapy, this cannot be achieved by applying a uniform distribution of absorbed dose within the target volume due to the drastic change in the biological effectiveness of ion beam as shown in the previous section. In this section, biophysical models used in carbon-ion radiotherapy (C-ion RT) at HIMAC are explained.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. International Commission on Radiation Units & Measurements. Prescribing, recording, and reporting proton-beam therapy (ICRU Report 78). Maryland: Bethesda; 2009.

    Google Scholar 

  2. Kanai T, Endo M, Minohara S, et al. Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy. Int J Radiat Oncol. 1999;44:201–10.

    Article  CAS  Google Scholar 

  3. Kanai T, Furusawa T, Fukutsu K, et al. Irradiation of mixed beam and design of spread-out Bragg peak for heavy-ion radiotherapy. Radiat Res. 1997;147:78–85.

    Article  CAS  PubMed  Google Scholar 

  4. Tsunemoto H. Clinical evaluation of fast neutron therapy. Nippon Igaku Hoshasen Gakkai Zasshi. 1982;42:823–47.

    CAS  PubMed  Google Scholar 

  5. Kutsutani-Nakamura Y. Treatment planning method in the use of the TDF biological equivalent concept in fast neutron therapy. Nippon Igaku Hoshasen Gakkai Zasshi. 1978;38:950–60.

    CAS  PubMed  Google Scholar 

  6. Miyamoto T, Yamamoto N, Nishimura H, et al. Carbon ion radiotherapy for stage I non-small cell lung cancer. Radiother Oncol. 2003;66:127–40.

    Article  PubMed  Google Scholar 

  7. Webb S, Nahum AE. A model for calculating tumour control probability in radiotherapy including the effects of inhomogeneous distributions of dose and clonogenic cell density. Phys Med Biol. 1993;38:653–66.

    Article  CAS  PubMed  Google Scholar 

  8. Matsufuji N, Kanai T, Kanematsu N, et al. Specification of carbon ion dose at the National Institute of Radiological Sciences (NIRS). J Radiat Res. 2007;48:A81–6.

    Article  PubMed  Google Scholar 

  9. Kanai T, Matsufuji N, Miyamoto T, et al. Examination of GyE system for HIMAC carbon therapy. Int J Radiat Oncol. 2006;64:650–6.

    Article  Google Scholar 

  10. Hawkins RB. A statistical theory of cell killing by radiation of varying linear energy transfer. Radiat Res. 1994;140:346–67.

    Article  Google Scholar 

  11. Kellerer AM, Rossi HH. A generalized formation of dual radiation action. Radiat Res. 1978;75:471–88.

    Article  Google Scholar 

  12. Kase Y, Kanai T, Matsumoto M, et al. Microdosimetric measurements and estimation of human cell survival for heavy-ion beams. Radiat Res. 2006;166:629–38.

    Article  CAS  PubMed  Google Scholar 

  13. Inaniwa T, Furukawa T, Kase Y, Matsufuji N, Toshito T, Matsumoto Y, Furusawa Y, Noda K. Treatment planning for a scanned carbon beam with a modified microdosimetric kinetic model. Phys Med Biol. 2010;55:6721–37.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. National Institute of Radiological Sciences, 9-1, Anagawa-4, Inage-ku, Chiba, 263-8555, Japan

    Naruhiro Matsufuji

Authors
  1. Naruhiro Matsufuji
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Naruhiro Matsufuji .

Editor information

Editors and Affiliations

  1. National Inst. of Radiological Sciences, Chiba, Chiba, Japan

    Hirohiko Tsujii

  2. NIRS, Chiba, Chiba, Japan

    Tadashi Kamada

  3. NIRS, Chiba, Chiba, Japan

    Toshiyuki Shirai

  4. NIRS, Chiba, Chiba, Japan

    Koji Noda

  5. NIRS, Chiba, Chiba, Japan

    Hiroshi Tsuji

  6. NIRS, Chiba, Chiba, Japan

    Kumiko Karasawa

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Japan

About this chapter

Cite this chapter

Matsufuji, N. (2014). Biophysical Models and RBE. In: Tsujii, H., Kamada, T., Shirai, T., Noda, K., Tsuji, H., Karasawa, K. (eds) Carbon-Ion Radiotherapy. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54457-9_5

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-54457-9_5

  • Published:

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-54456-2

  • Online ISBN: 978-4-431-54457-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation