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Biomarkers of Endometriosis

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Endometriosis

Abstract

Endometriosis is a benign gynecological disease defined by the ectopic presence of endometrium and associated with pelvic pain and infertility. The etiology and pathogenesis remain unclear. The gold standard of diagnosing endometriosis is laparoscopy followed by histological confirmation, associated with an 8-year delay in the diagnosis of endometriosis. A clinically reliable test for endometriosis can be expected to allow early diagnosis and treatment, with profound impact on the reduction of health care and individual costs. A noninvasive diagnostic test could be developed for serum or plasma, urine, and endometrial or menstrual fluid. A semi-invasive test could be developed for peritoneal fluid and eutopic endometrium. The development of such a test from initial biomarker discovery to be a clinically approved biomarker assay is a long, difficult, and uncertain process and includes four different phases. A review of the existing literature is provided in this chapter. Overall, most endometriosis biomarker studies remain at the level of phase I, with only a few currently in phase II of biomarker development. There is a need for a well-designed multinational study including academic and industrial partners for phase II and phase III trials.

*Amelie Fassbender and Dorien O are joint first authors

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Authors and Affiliations

  1. Department of Development and Regeneration, Organ systems, KU Leuven, Leuven, Belgium

    Amelie Fassbender, Dorien O & Thomas D’Hooghe

  2. Department of Obstetrics and Gynaecology, Leuven University Fertility Centre, University Hospital Leuven, UZ Gasthuisberg, Leuven, Belgium

    Amelie Fassbender, Dorien O, Christel Meuleman, Carla Tomassetti, Karen Peeraer & Thomas D’Hooghe

  3. Department of Electrical Engineering (ESAT-SCD), KU Leuven, Leuven, Belgium

    Bart De Moor

  4. Department of Molecular Cell Biology, Campus Gasthuisberg, Leuven, Belgium

    Etienne Waelkens

  5. Division of Reproductive Biology, Institute of Primate Research, Karen, Nairobi, Kenya

    Thomas D’Hooghe

Authors
  1. Amelie Fassbender
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  2. Dorien O
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  3. Bart De Moor
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  4. Etienne Waelkens
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  5. Christel Meuleman
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  6. Carla Tomassetti
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  7. Karen Peeraer
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  8. Thomas D’Hooghe
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Corresponding author

Correspondence to Thomas D’Hooghe .

Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology, Tottori University Faculty of Medicine, Yonago, Tottori, Japan

    Tasuku Harada

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Fassbender, A. et al. (2014). Biomarkers of Endometriosis. In: Harada, T. (eds) Endometriosis. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54421-0_20

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  • DOI: https://doi.org/10.1007/978-4-431-54421-0_20

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