Thrombotic Thrombocytopenic Purpura and Thrombotic Microangiopathy

  • Kenjiro Honda
  • Kent Doi


  • Plasma exchange (PE) should be immediately undergone in the probable cases of thrombotic thrombocytopenic purpura (TTP)/thrombotic microangiopathy (TMA) with thrombocytopenia, erythrocyte fragmentation, and hemolytic anemia.

  • Replacement of 1–1.5 times the plasma volume with fresh frozen plasma (FFP) during a single procedure of PE is appropriate. PE should be continued until recovery of appropriate laboratory test values and resolution of neurological symptoms, usually after daily PE for 3–5 days.

  • The effectiveness of PE is controversial, especially in O157-induced hemolytic-uremic syndrome (HUS)/TMA in children


Plasma Exchange Disseminate Intravascular Coagulation Fresh Freeze Plasma Thrombotic Thrombocytopenic Purpura Inhibitor Titer 
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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Department of Nephrology and EndocrinologyUniversity Hospital, The University of TokyoTokyoJapan
  2. 2.Department of Emergency and Critical Care MedicineUniversity Hospital, The University of TokyoTokyoJapan

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