Thrombotic Thrombocytopenic Purpura and Thrombotic Microangiopathy
Plasma exchange (PE) should be immediately undergone in the probable cases of thrombotic thrombocytopenic purpura (TTP)/thrombotic microangiopathy (TMA) with thrombocytopenia, erythrocyte fragmentation, and hemolytic anemia.
Replacement of 1–1.5 times the plasma volume with fresh frozen plasma (FFP) during a single procedure of PE is appropriate. PE should be continued until recovery of appropriate laboratory test values and resolution of neurological symptoms, usually after daily PE for 3–5 days.
The effectiveness of PE is controversial, especially in O157-induced hemolytic-uremic syndrome (HUS)/TMA in children
KeywordsPlasma Exchange Disseminate Intravascular Coagulation Fresh Freeze Plasma Thrombotic Thrombocytopenic Purpura Inhibitor Titer