Blood Type Incompatible Pregnancies

  • Norio Hanafusa


  • Antigens inherited from the father that the mother does not possess can be immunogenic when produced by the fetus, and antibodies can be produced in the maternal body against such antigens.

  • Antibodies against paternal antigens on red blood cells can cause hemolytic anemia of the fetus.

  • Fetal blood transfusion can be performed successfully in later gestation. However, during early gestation, until fetal blood transfusion can be performed safely, apheresis is applied.


Hemolytic Anemia Factor Xiii Blood Group Antigen Neonatal Jaundice Fetal Edema 
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  1. 1.
    Hanafusa N et al (2006) Successful treatment by double filtrate plasmapheresis in a pregnant woman with the rare P blood group and a history of multiple early miscarriages. Ther Apher Dial 10(6):498–503PubMedCrossRefGoogle Scholar
  2. 2.
    Omokawa S (2008) Blood purification therapy 2009: blood type incompatible pregnancy. Kidney Dial 65(Suppl):417–420 (in Japanese)Google Scholar
  3. 3.
    Sato A (2007) Diagnosis, therapy and management of obstetric disease: blood type incompatible pregnancy. J Jpn Obstet Gynecol Soc 59(12):N719–23 (in Japanese)Google Scholar
  4. 4.
    Hanafusa N et al (2007) Double filtration plasmapheresis can decrease factor XIII activity. Ther Apher Dial 11(3):165–70PubMedCrossRefGoogle Scholar
  5. 5.
    Frampton G et al (1987) Successful removal of anti-phospholipid antibody during pregnancy using plasma exchange and low-dose prednisolone. Lancet 2(8566):1023–4PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Department of Hemodialysis & ApheresisUniversity Hospital, The University of TokyoTokyoJapan

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