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Sudden Infant Death Syndrome from the Perspective of Arousal Deficiency

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Abstract

In Japan, it is mandatory to undertake efforts to prevent sudden infant death syndrome (SIDS), which continues to be responsible for a large portion of infant mortality. Etiological investigations of SIDS have been conducted independently in areas of epidemiology, physiology, and pathology, but mechanisms underlying the syndrome remain unknown. We conducted a comprehensive study which combined these disciplines. A theory of incomplete arousal has emerged for a pathophysiological hypothesis of SIDS, derived from reevaluation of a previously proposed apnea concept. As a consequence of this comprehensive study, we demonstrate that a tendency for arousal is reduced when an otherwise normal infant is subjected to epidemiological risk factors for SIDS and that a phenomenon of incomplete wakefulness exists in SIDS infants. Humans do not succumb solely because of incomplete arousal. According to the results of comprehensive examnation, the linking of pysiological and pathological data in single individuals, suggest that a change in neuronal plasticity of arousal pathways of the brain stem occurs, altering the basis for recognition and memory for a hypoxic state, thus triggering an infant’s untimely death.

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Acknowledgments

This review was supported by Japan Society for the Promotion of Science under the JAPAN-Belgium Research Cooperative Program.

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Authors and Affiliations

  1. Institute of Advanced Biomedical Engineering Sciences, Tokyo Women’s Medical University School of Medicine, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan

    Toshiko Sawaguchi

  2. Pediatric Sleep Unit, Hôpital Femme Mère Enfant and CRNL, INSERM-U1028, CNRS UMR5292 University Lyon 1, Lyon, France

    Patricia Franco

  3. Brussels Free University Children’s Hospital Reine Fabiola, Brussels, B-1020, Belgium

    Hazim Kadhim & André Kahn

  4. University Lyon 1, Lyon, France

    Hazim Kadhim & André Kahn

  5. Department of Pharmaceutical Toxicology, School of Pharmacy of Pharmaceutical Sciences, Hoshi University, Shinagawa, Tokyo, 142-8502, Japan

    Tomohisa Mori

  6. Coop.I.T.O, Musashino, Tokyo, 180-006, Japan

    Shinobu Ito

  7. Department of Legal Medicine, School of Medicine, Tokyo Women’s Medical University, Tokyo, 162-8666, Japan

    Takashi Taki

  8. School of Social Welfare, Tokyo University and Graduate School of Social Welfare, Isezaki, Gunma, 372-0837, Japan

    Akiko Sawaguchi

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  1. Toshiko Sawaguchi
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  8. André Kahn
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Correspondence to Toshiko Sawaguchi .

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  1. Inst of Advanced Biomedical Engineering Tokyo Women's Medical University, Tokyo, Tokyo, Japan

    Toshiko Sawaguchi

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Sawaguchi, T. et al. (2014). Sudden Infant Death Syndrome from the Perspective of Arousal Deficiency. In: Sawaguchi, T. (eds) Sudden Infant Death Syndrome. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54315-2_6

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