Abstract
High biocompatibility is one of the main features expected of an intraocular lens (IOL) implant. In terms of anatomical position an implant is close to, or in contact with, uveal tissue and the capsule. Therefore, uveal reactions of the eye must be distinguished from capsular reactions. As both reactions are influenced by the implant, one should rightly address the subjects of uveal biocompatibility and capsular biocompatibility separately. The iris, the ciliary body, and the choroid are composed of vascularized tissue and are close to the implant. In cases of iridolenticular synechiae or sulcus position of the IOL, portions of the lens come into direct contact with uveal tissue. Changes in blood-aqueous barrier due to surgical trauma and the implanted foreign body cause leakage of proteins and macrophages from blood.
The main parameters of capsular biocompatibility are lens epithelial cell (LEC) outgrowth, anterior capsule opacification (ACO), posterior capsule opacification (PCO), and contraction of the capsule; IOLs that perform well in these respects may be said to possess high capsular biocompatibility.
The foreign-body cell reaction is the most important parameter of uveal biocompatibility; IOLs causing a very mild foreign-body reaction could be rightly referred to as IOLs with uveal biocompatibility. Implants with high uveal biocompatibility are especially suitable for eyes with a compromised blood-aqueous barrier (BAB).
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Amon, M., Kahraman, G. (2014). Capsular and Uveal Biocompatibility of Different IOLs in Eyes With and Without Associated Conditions. In: Saika, S., Werner, L., Lovicu, F. (eds) Lens Epithelium and Posterior Capsular Opacification. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54300-8_18
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DOI: https://doi.org/10.1007/978-4-431-54300-8_18
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