Abstract
Intraocular lens characteristics may influence the outcome of posterior capsule opacification. Different studies have described the possible roles of material and design on the prevention of this complication, which are discussed in this chapter. These include studies evaluating material properties, particularly adhesive properties leading to different patterns of protein adsorption on the lens surfaces. The most important intraocular lens feature in posterior capsule opacification prevention with in-the-bag fixated intraocular lenses was found to be the presence of a square edge on the posterior optic surface. Nevertheless, studies evaluating the microstructure of the edges of currently available foldable intraocular lenses found that all square edges in the market are not equally square. As a group, hydrophilic acrylic lenses were found to have less square edges than hydrophobic acrylic and silicone lenses. Furthermore, animal and clinical studies demonstrated that the square edge should be present for 360 around the lens optic, for maximal efficiency in terms of prevention of posterior capsule opacification.
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References
Apple D, Peng Q, Visessook N et al (2001) Eradication of posterior capsule opacification: documentation of a marked decrease in Nd:YAG laser posterior capsulotomy rates noted in an analysis of 5416 pseudophakic human eyes obtained postmortem. Ophthalmology 108(3):505–518
Oshika T, Nagata T, Ishii Y (1998) Adhesion of lens capsule to intraocular lenses of polymethylmethacrylate, silicone, and acrylic foldable materials: an experimental study. Br J Ophthalmol 82:549–553
Linnola R, Salonen J, Happonen R (1999) Intraocular lens bioactivity tested using rabbit corneal tissue cultures. J Cataract Refract Surg 25:1480–1485
Nagata T, Minakata A, Watanabe I (1998) Adhesiveness of AcrySof to a collagen film. J Cataract Refract Surg 24:367–370
Linnola RJ, Sund M, Ylönen R, Pihlajaniemi T (2003) Adhesion of soluble fibronectin, vitronectin, and collagen type IV to intraocular lens materials. J Cataract Refract Surg 29(1):146–152
Linnola R, Werner L, Pandey S et al (2000) Adhesion of fibronectin, vitronectin, laminin, and collagen type IV to intraocular lens materials in pseudophakic human autopsy eyes Part 1: histological sections. J Cataract Refract Surg 26:1792–1806
Linnola R, Werner L, Pandey S et al (2000) Adhesion of fibronectin, vitronectin, laminin, and collagen type IV to intraocular lens materials in pseudophakic human autopsy eyes Part 2: Explanted intraocular lenses. J Cataract Refract Surg 26:1807–1818
Johnston R, Spalton D, Hussain A, Marshall J (1999) In vitro protein adsorption to 2 intraocular lens materials. J Cataract Refract Surg 25:1109–1115
Ursell P, Spalton D, Pande M (1997) Anterior capsule stability in eyes with intraocular lenses made of poly(methyl methacrylate), silicone, and AcrySof. J Cataract Refract Surg 23:1532–1538
Werner L, Pandey S, Escobar-Gomez M et al (2000) Anterior capsule opacification: a histopathological study comparing different IOL styles. Ophthalmology 107:463–471
Werner L, Pandey SK, Apple DJ et al (2001) Anterior capsule opacification: correlation of pathological findings with clinical sequelae. Ophthalmology 108:1675–1681
Nishi O, Nishi K, Sakanishi K (1998) Inhibition of migrating lens epithelial cells at the capsular bend created by the rectangular optic edge of a posterior chamber intraocular lens. Ophthalmic Surg Lasers 29:587–594
Schauersberger J, Amon M, Kruger A et al (2001) Comparison of the biocompatibility of 2 foldable intraocular lenses with sharp optic edges. J Cataract Refract Surg 27:1579–1585
Buehl W, Findl O, Menapace R et al (2002) Effect of an acrylic intraocular lens with a sharp posterior optic edge on posterior capsule opacification. J Cataract Refract Surg 28:1105–1111
Prosdocimo G, Tassinari G, Sala M et al (2003) Posterior capsule opacification after phacoemulsification: silicone CeeOn Edge versus acrylate AcrySof intraocular lens. J Cataract Refract Surg 29:1551–1555
Auffarth G, Golescu A, Becker K, Volcker H (2003) Quantification of posterior capsule opacification with round and sharp edge intraocular lenses. Ophthalmology 110:772–780
Nixon DR (2004) In vivo digital imaging of the square-edged barrier effect of a silicone intraocular lens. J Cataract Refract Surg 30:2574–2584
Peng Q, Visessook N, Apple DJ et al (2000) Surgical prevention of posterior capsule opacification. Part 3. Intraocular lens optic barrier effect as a second line of defense. J Cataract Refract Surg 26:198–213
Werner L, Mamalis N, Izak AM et al (2005) Posterior capsule opacification in rabbit eyes implanted with single-piece and three-piece hydrophobic acrylic intraocular lenses. J Cataract Refract Surg 31:805–811
Nishi O, Nishi K (1999) Preventing posterior capsule opacification by creating a discontinuous sharp bend in the capsule. J Cataract Refract Surg 25:521–526
Nishi O, Yamamoto N, Nishi K, Nishi Y (2007) Contact inhibition of migrating lens epithelial cells at the capsular bend created by a sharp-edged intraocular lens after cataract surgery. J Cataract Refract Surg 33:1065–1070
Bhermi G, Spalton D, El-Osta MJ (2002) Failure of a discontinuous bend to prevent lens epithelial cell migration in vitro. J Cataract Refract Surg 28:1256–1261
Boyce J, Bhermi G, Spalton D, El-Osta A (2002) Mathematic modeling of the forces between an intraocular lens and the capsule. J Cataract Refract Surg 28:1853–1859
Tetz M, Wildeck A (2005) Evaluating and defining the sharpness of intraocular lenses: part 1: influence of optic design on the growth of the lens epithelial cells in vitro. J Cataract Refract Surg 31:2172–2179
Werner L, Muller M, Tetz M (2008) Evaluating and defining the sharpness of intraocular lenses. Microedge structure of commercially available square-edged hydrophobic lenses. J Cataract Refract Surg 34:310–317
Werner L, Tetz M, Feldmann I et al (2009) Evaluating and defining the sharpness of intraocular lenses. Microedge structure of commercially available square-edged hydrophilic lenses. J Cataract Refract Surg 35:556–566
Nanavaty M, Spalton D, Boyce J et al (2008) Edge profile of commercially available square-edged intraocular lenses. J Cataract Refract Surg 34:677–686
Kugelberg M, Wejde G, Jayaram H, Zetterström C (2006) Posterior capsule opacification after implantation of a hydrophilic or a hydrophobic acrylic intraocular lens: one-year follow-up. J Cataract Refract Surg 32:1627–1631
Kugelberg M, Wejde G, Jayaram H, Zetterström C (2008) Two-year follow-up of posterior capsule opacification after implantation of a hydrophilic or hydrophobic acrylic intraocular lens. Acta Ophthalmol 86:533–536
Richter-Mueksch S, Kahraman G, Amon M et al (2007) Uveal and capsular biocompatibility after implantation of sharp-edged hydrophilic acrylic, hydrophobic acrylic, and silicone intraocular lenses in eyes with pseudoexfoliation syndrome. J Cataract Refract Surg 33:1414–1418
Cheng J, Wei R, Cai J et al (2007) Efficacy of different intraocular lens materials and optic edge designs in preventing posterior capsular opacification: a meta-analysis. Am J Ophthalmol 143:428–436
Heatley CJ, Spalton D, Kumar A et al (2005) Comparison of posterior capsule opacification rates between hydrophilic and hydrophobic single-piece acrylic intraocular lenses. J Cataract Refract Surg 31:718–724
Vargas LG, Izak AM, Apple DJ et al (2003) Implantation of a single-piece, hydrophilic, acrylic, minus-power foldable posterior chamber intraocular lens in a rabbit model: clinicopathologic study of posterior capsule opacification. J Cataract Refract Surg 29:1613–1620
Werner L, Mamalis N, Pandey S et al (2004) Posterior capsule opacification in rabbit eyes implanted with hydrophilic acrylic intraocular lenses with enhanced square edge. J Cataract Refract Surg 30:2403–2409
Nishi Y, Rabsilber TM, Limberger IJ et al (2007) Influence of 360-degree enhanced optic edge design of a hydrophilic acrylic intraocular lens on posterior capsule opacification. J Cataract Refract Surg 33(2):227–231
Sacu S, Finle O, Menapace R et al (2004) Comparison of posterior capsule opacification between the 1-piece and 3-piece AcrySof intraocular lenses; two-year results of a randomized trial. Ophthalmology 111:1840–1846
Leydolt C, Davidovic S, Sacu S et al (2007) Long-term effect of 1-piece and 3-piece hydrophobic acrylic intraocular lens on posterior capsule opacification; a randomized trial. Ophthalmology 114:1663–1669
Bender L, Nimsgern C, Jose R et al (2004) Effect of 1-piece and 3-piece AcrySof intraocular lenses on the development of posterior capsule opacification after cataract surgery. J Cataract Refract Surg 30:786–789
Ness PJ, Werner L, Maddula S et al (2011) Pathology of 219 human cadaver eyes with 1-piece or 3-piece hydrophobic acrylic intraocular lenses: capsular bag opacification and sites of square-edged barrier breach. J Cataract Refract Surg 37:923–930
Nixon DR, Woodcock MG (2010) Pattern of posterior capsule opacification models 2 years postoperatively with 2 single-piece acrylic intraocular lenses. J Cataract Refract Surg 36(6):929–934
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Morris, C., Werner, L., Tetz, M. (2014). PCO Prevention: IOL Material Versus IOL Design. In: Saika, S., Werner, L., Lovicu, F. (eds) Lens Epithelium and Posterior Capsular Opacification. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54300-8_17
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DOI: https://doi.org/10.1007/978-4-431-54300-8_17
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