Abstract
These lesions refer to multiple areas of the esophagus not staining with iodine when sprayed with iodine stain. Lesions that do not stain with iodine include areas of inflammation, atypical epithelium, intraepithelial cancers, and invasive cancers, whereas squamous cell carcinoma is extremely likely with a positive pink color sign, a pink color change following iodine staining. Multiple Lugol-voiding lesions are seen in individuals with ALDH2 deficiency who habitually consume alcohol, and they are at an increased risk of multiple cancers of the esophagus and laryngopharyngeal region.
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Muto, M. et al. (2015). Atlas of Neoplastic Lesions. In: Muto, M., Yao, K., Sano, Y. (eds) Atlas of Endoscopy with Narrow Band Imaging. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54243-8_6
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