Conclusion

Abstract

The contents in this thesis are summarized in this chapter. I developed novel asymmetric bifunctional organocatalysts based on the previously developed amino thiourea catalyst. One of them is the development of the quinazoline and benzothiadiazine catalysts, which could be used as novel HB donors. I succeeded in developing the first asymmetric organocatalytic Michael reaction of α,β-unsaturated carboxylic acid derivatives and several activated methylene compounds. In addition, it was found that the highly enantioselective hydrazination of activated methylene compounds occurred in the presence of the novel quinazoline catalysts. The other content is the development of the novel hydroxy thiourea catalysts. Both catalysts could be applied to asymmetric reactions involving the organoboronic acids, which could not be utilized under the conditions of the previous amino thiourea catalysts.