History: Lacrimal and Salivary Glands

  • Susumu Sugai


In this paper, I look back over the history of the diseases affecting mainly the lacrimal and salivary glands: Mikulicz’s disease and Sjögren’s syndrome, in relation to the new disease concept of IgG4-related disease which was proposed from Japan and has become recognized as a systemic disorder characterized by high serum IgG4 concentrations and abundant IgG4-positive plasma cell infiltration in affected organs.

Since the first report of Mikulicz’s disease considerable confusion persisted for 65 years, but which then appeared to settle as a subset of Sjögren’s syndrome in 1953. However, only after 50 years was Mikulicz’s disease recognized as a major manifestation of the broader concept of IgG4-related disease.


Salivary Gland Parotid Gland Submandibular Gland Lacrimal Gland Autoimmune Pancreatitis 
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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Kudoh General HospitalKaga CityJapan

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