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History: Lacrimal and Salivary Glands

  • Susumu Sugai
Chapter

Abstract

In this paper, I look back over the history of the diseases affecting mainly the lacrimal and salivary glands: Mikulicz’s disease and Sjögren’s syndrome, in relation to the new disease concept of IgG4-related disease which was proposed from Japan and has become recognized as a systemic disorder characterized by high serum IgG4 concentrations and abundant IgG4-positive plasma cell infiltration in affected organs.

Since the first report of Mikulicz’s disease considerable confusion persisted for 65 years, but which then appeared to settle as a subset of Sjögren’s syndrome in 1953. However, only after 50 years was Mikulicz’s disease recognized as a major manifestation of the broader concept of IgG4-related disease.

Keywords

Salivary Gland Parotid Gland Submandibular Gland Lacrimal Gland Autoimmune Pancreatitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Kudoh General HospitalKaga CityJapan

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