IgG4-related disease (IgG4-RD) has come to be recognized as a systemic disorder characterized by high serum IgG4 concentrations and abundant IgG4-positive plasma cell infiltration in affected organs. Autoimmune pancreatitis (AIP) is a major manifestation of this condition, whose close association with IgG4 has been intensively investigated. In this chapter, we focused on the history of the association between AIP and IgG4, which led to the proposal of the new disease concept of IgG4-RD.
KeywordsMain Pancreatic Duct Autoimmune Pancreatitis Serum IgG4 Concentration Japan Pancreas Society Obliterative Phlebitis
- 5.Comings DE, Skubi KB, Van Eyes J, et al. Familial multifocal fibrosclerosis. Findings suggesting that retroperitoneal fibrosis, mediastinal fibrosis, sclerosing cholangitis, Riedel's thyroiditis, and pseudotumor of the orbit may be different manifestations of a single disease. Ann Intern Med. 1967;66:884–92.PubMedCrossRefGoogle Scholar
- 6.Toki F, Kozu T, Oi I, et al. An unusual type of chronic pancreatitis showing diffuse irregular narrowing of the entire main pancreatic duct on ERCP-A report of four cases. Endoscopy. 1992;24:640.Google Scholar