Abstract
Positron emission tomography (PET) with 18F fluorodeoxyglucose (FDG) is an effective method for screening throughout the entire body for organ lesions associated with IgG4-related disease (IgG4-RD). FDG, a tracer of glucose metabolism, accumulates in areas of active inflammatory changes, which are associated with enhanced glucose metabolism. In IgG4-RD, abnormal accumulation can be detected in type 1 autoimmune pancreatitis (AIP), salivary and lacrimal gland lesions, retroperitoneal fibrosis, nephritis, and other areas of high activity, all reflective of pathological changes occurring in this condition. It is also anticipated that this imaging modality will be a useful approach to the assessment of responses to treatment. Although there are still few systematic reports on PET examinations in IgG4-RD, we outline here some representative cases in which it was found useful, and consider its role in this disease.
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Nakamoto Y, Sakahara H, Higashi T, Saga T, Sato N, Okazaki K, et al. Autoimmune pancreatitis with F-18 fluoro-2-deoxy-D-glucose PET findings. Clin Nucl Med. 1999;24:778–80.
Nakamoto Y, Saga T, Ishimori T, Higashi T, Mamede M, Okazaki K, et al. FDG-PET of autoimmune-related pancreatitis: preliminary results. Eur J Nucl Med. 2000;27:1835–8.
Nakajo M, Jinnouchi S, Fukukura Y, Tanabe H, Tateno R. The efficacy of whole-body FDG-PET or PET/CT for autoimmune pancreatitis and associated extrapancreatic autoimmune lesions. Eur J Nucl Med Mol Imaging. 2007;34:2088–95.
Otsuka H, Morita N, Yamashita K, Nishitani H. FDG-PET/CT findings of autoimmune pancreatitis associated with idiopathic retroperitoneal fibrosis. Ann Nucl Med. 2007;21:593–6.
Lee TY, Kim MH, Park do H, Seo DW, Lee SK, Kim JS, et al. Utility of 18F-FDG PET/CT for differentiation of autoimmune pancreatitis with atypical pancreatic imaging findings from pancreatic cancer. AJR Am J Roentgenol. 2009;193:343–8.
Kamisawa T, Okamoto A. IgG4-related sclerosing disease. World J Gastroenterol. 2008;14:3948–55.
Kawamura E, Habu D, Higashiyama S, Tsushima H, Shimonishi Y, Nakayama Y, et al. A case of sclerosing cholangitis with autoimmune pancreatitis evaluated by FDG-PET. Ann Nucl Med. 2007;21:223–8.
Sawai H, Matsubayashi H, Sasaki K, Tanaka M, Kakushima N, Takizawa K, et al. A case of sclerosing cholangitis without pancreatic involvement thought to be associated with autoimmunity. Intern Med. 2011;50:433–8.
Tanabe T, Tsushima K, Yasuo M, Urushihata K, Hanaoka M, Koizumi T, et al. IgG4-associated multifocal systemic fibrosis complicating sclerosing sialadenitis, hypophysitis, and retroperitoneal fibrosis, but lacking pancreatic involvement. Intern Med. 2006;45:1243–7.
Suga K, Kawakami Y, Hiyama A, Hori K, Takeuchi M. F-18 FDG PET-CT findings in mikulicz disease and systemic involvement of IgG4-related lesions. Clin Nucl Med. 2009;34:164–7.
Kim F, Yamada K, Inoue D, Nakajima K, Mizushima I, Kakuchi Y, et al. IgG4-related tubulointerstitial nephritis and hepatic inflammatory pseudotumor without hypocomplementemia. Intern Med. 2011;50:1239–44.
Nguyen VX, De Petris G, Nguyen BD. Usefulness of PET/CT imaging in systemic IgG4-related sclerosing disease. A report of three cases. JOP. 2011;12:297–305.
Hamano H, Kawa S, Horiuchi A, Unno H, Furuya N, Akamatsu T, et al. High serum IgG4 concentrations in patients with sclerosing pancreatitis. N Engl J Med. 2001;344:732–8.
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Nakajima, K., Inaki, A., Mochizuki, T., Kinuya, S., Kawano, M. (2014). Positron Emission Tomography with F-18 Fluorodeoxyglucose. In: Umehara, H., Okazaki, K., Stone, J., Kawa, S., Kawano, M. (eds) IgG4-Related Disease. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54228-5_20
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DOI: https://doi.org/10.1007/978-4-431-54228-5_20
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