Scintigraphy and Single-Photon Emission Computed Tomography

  • Kenichi Nakajima
  • Anri Inaki
  • Seigo Kinuya
  • Takashi Wada
  • Mitsuhiro Kawano


Scintigraphy with single-photon radionuclides is a useful means of detecting various functional abnormalities in organs affected by IgG4-related disease (IgG4-RD). Notable examples include 67Ga to depict the inflammatory activity associated with IgG4-RD, salivary gland scintigraphy to delineate the degree of salivary gland injury, and renal scintigraphy to quantify changes in blood flow and functional impairment in the presence of renal lesions. In particular, 67Ga scintigraphy is a modality that detects systemic inflammatory changes and can be used to evaluate the activity of lesions within the pancreas, lung, kidney, salivary gland, and lymph nodes. Current use of the combined system of single-photon emission computed tomography (SPECT)-CT can further facilitate localization of regions in which abnormal accumulation of 67Ga is observed. Scintigraphic findings are not specific for the lesions of IgG4-RD. Thus, the main roles of this imaging modality are to clarify the degree of inflammatory activity, to determine the extent of organ injury, and to assess the effect of therapy by comparing studies before and after treatment.


Salivary Gland Submandibular Gland Washout Rate Serum IgG4 Concentration 67Ga Scintigraphy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Saegusa H, Momose M, Kawa S, Hamano H, Ochi Y, Takayama M, et al. Hilar and pancreatic gallium-67 accumulation is characteristic feature of autoimmune pancreatitis. Pancreas. 2003;27:20–5.PubMedCrossRefGoogle Scholar
  2. 2.
    Ando N, Yasuda I, Saito M, Moriwaki H. Hilar lymphadenopathy associated with autoimmune pancreatitis. Pancreas. 2006;33:101–2.PubMedCrossRefGoogle Scholar
  3. 3.
    Saeki T, Nishi S, Ito T, Yamazaki H, Miyamura S, Emura I, et al. Renal lesions in IgG4-related systemic disease. Intern Med. 2007;46:1365–71.PubMedCrossRefGoogle Scholar
  4. 4.
    Tsushima K, Tanabe T, Yamamoto H, Koizumi T, Kawa S, Hamano H, et al. Pulmonary involvement of autoimmune pancreatitis. Eur J Clin Invest. 2009;39:714–22.PubMedCrossRefGoogle Scholar
  5. 5.
    Fujinaga Y, Kadoya M, Kawa S, Hamano H, Ueda K, Momose M, et al. Characteristic findings in images of extra-pancreatic lesions associated with autoimmune pancreatitis. Eur J Radiol. 2010;76:228–38.PubMedCrossRefGoogle Scholar
  6. 6.
    Momose M, Kadoya M, Yano K, Miyasaka T, Fujinaga Y, Matsushita T, et al. Semiquantitative measurement of pulmonary hilar gallium-67 uptake using single photon emission computed tomography/computed tomography for the diagnosis of autoimmune pancreatitis. Jpn J Radiol. 2010;28:733–9.PubMedCrossRefGoogle Scholar
  7. 7.
    Ishii S, Shishido F, Miyajima M, Sakuma K, Shigihara T, Kikuchi K. Whole-body gallium-67 scintigraphic findings in IgG4-related disease. Clin Nucl Med. 2011;36:542–5.PubMedCrossRefGoogle Scholar
  8. 8.
    Aoki A, Sato K, Itabashi M, Takei T, Yoshida T, Arai J, et al. A case of Mikulicz's disease complicated with severe interstitial nephritis associated with IgG4. Clin Exp Nephrol. 2009;13:367–72.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 2014

Authors and Affiliations

  • Kenichi Nakajima
    • 1
  • Anri Inaki
    • 1
  • Seigo Kinuya
    • 1
  • Takashi Wada
    • 2
  • Mitsuhiro Kawano
    • 3
  1. 1.Department of Nuclear MedicineKanazawa UniversityKanazawaJapan
  2. 2.Division of Nephrology, Department of Laboratory MedicineKanazawa UniversityKanazawaJapan
  3. 3.Division of RheumatologyKanazawa University HospitalKanazawaJapan

Personalised recommendations