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Nerve Lesions

  • Yasunari Fujinaga
  • Tomoharu Watanabe
  • Satoshi Kawakami
  • Masumi Kadoya
  • Hideaki Hamano
  • Shigeyuki Kawa
Chapter

Abstract

It is now widely recognized that type 1 autoimmune pancreatitis (AIP), which pathologically corresponds to lymphoplasmacytic sclerosing pancreatitis (LPSP), is part of the IgG4-related disease (IgG4-RD) spectrum and is associated with a wide range of extrapancreatic lesions. However, little has been written to date about peripheral nerve involvement in this condition. We analyzed the relationship between type 1 AIP and infraorbital nerve swelling and identified a significantly higher frequency of nerve swelling as compared to that of a control group. In addition, we observed that the infraorbital nerve lesions responded well to glucocorticoid therapy. Infraorbital nerve swelling was also associated with other organ involvement typical of IgG4-RD, namely lacrimal, submandibular, and parotid gland disease and enlargement of the extraocular muscles. These results are consistent with the concept that infraorbital nerve swelling is a common peripheral nerve lesion in patients with type 1 AIP and IgG4-RD.

Keywords

Lacrimal Gland Extraocular Muscle Nerve Lesion Autoimmune Pancreatitis Chronic Inflammatory Demyelinating Polyneuropathy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2014

Authors and Affiliations

  • Yasunari Fujinaga
    • 1
  • Tomoharu Watanabe
    • 1
  • Satoshi Kawakami
    • 1
  • Masumi Kadoya
    • 1
  • Hideaki Hamano
    • 2
  • Shigeyuki Kawa
    • 3
  1. 1.Department of RadiologyShinshu University School of MedicineMatsumoto CityJapan
  2. 2.Division of Medical Informatics, Department of Internal medicine, GastroenterologyShinshu University HospitalMatsumoto CityJapan
  3. 3.Center for Health, Safety, and Environmental ManagementShinshu UniversityMatsumoto CityJapan

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