Lung Lesions

  • Dai Inoue
  • Yoh Zen
  • Shoko Matsui
  • Yuko Waseda
  • Osamu Matsui
  • Toshifumi Gabata


IgG4-related lung lesions are characterized by inflammatory cell infiltration and fibrosis occurring in the connective tissue (lymph tract) within the lung, mainly along the bronchovascular bundle, interlobular septa, and alveolar interstitium. As a result, diagnostic imaging studies often reveal ground-glass opacities and thickening of bronchovascular bundle and interlobular septa. In addition, some cases demonstrate mass lesions that must be differentiated from primary lung cancer.

Classification into four types on the basis of CT findings is possible: (1) solid, nodular lesions; (2) rounded ground-glass opacities (GGO); (3) alveolar-interstitial lesions; and (4) a bronchovascular pattern. Each of these types must be differentiated from other disorders that can present with similar radiologic findings. Comprehensive diagnosis must also consider the serum IgG4 concentration; the presence or absence of other organ involvement; and, whenever possible, the pulmonary histopathology.


Inflammatory Cell Infiltration Lung Lesion Autoimmune Pancreatitis Serum IgG4 Concentration Interlobular Septum 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Japan 2014

Authors and Affiliations

  • Dai Inoue
    • 1
    • 2
  • Yoh Zen
    • 3
  • Shoko Matsui
    • 4
  • Yuko Waseda
    • 5
  • Osamu Matsui
    • 1
  • Toshifumi Gabata
    • 1
  1. 1.Department of RadiologyKanazawa UniversityKanazawaJapan
  2. 2.Department of RadiologyToyama Prefectural Central HospitalToyama CityJapan
  3. 3.Institute of Liver StudiesKing’s College HospitalLondonUK
  4. 4.Health Administration CenterUniversity of ToyamaToyama cityJapan
  5. 5.Department of Respiratory MedicineKanazawa UniversityKanazawaJapan

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