Abstract
Since clarification of the relationship between Mikulicz’s disease and IgG4-related disease (IgG4-RD), basic research and clinical work on IgG4-RD in ophthalmology have progressed considerably, particularly with regard to the lacrimal gland lesions. Although it is clear that the lacrimal gland is the most common of the various orbital structures to be involved by IgG4-RD, other orbital structures are also involved with a high frequency, particularly the extraocular muscles and infraorbital nerve. Moreover, IgG4-related lesions may extend from the orbit to affect adjacent structures in the orbital apex, the lacrimal drainage system, and the eyeball. “IgG4-related ophthalmic disease” has been proposed as an appropriate term that encompasses disease involvement at all of these sites. Among inflammatory and lymphoproliferative disorders of the orbit, approximately one fourth appear to be associated with IgG4-RD.
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References
Goto H. Review of ocular tumor. In: Goto H, editor. Practical ophthalmology (Japanese), vol. 24. Tokyo: Bunkodo; 2008. p. 2–9.
Ohtsuka K, Hashimoto M, Suzuki Y. A review of 244 orbital tumors in Japanese patients during a 21-year period: origins and locations. Jpn J Ophthalmol. 2005;49:49–55.
Shields JA, Shields CL, Scartozzi R. Survey of 1264 patients with orbital tumors and simulating lesions: the 2002 Montgomery Lecture, part I. Ophthalmology. 2004;111:997–1008.
McKelvie PA. Ocular adnexal lymphomas: a review. Adv Anat Pathol. 2010;17:251–61.
Shinder R, Al-Zubidi N, Esmaeli B. Survey of orbital tumors at a comprehensive cancer center in the United States. Head Neck. 2011 May;33(5):610–4.
Sato Y, Ohshima K, Ichimura K, et al. Ocular adnexal IgG4-related disease has uniform clinicopathology. Pathol Int. 2008;58:465–70.
Cheuk W, Yuen HK, Chan JK. Complication of IgG4-related chronic sclerosing dacryoadenitis by lymphoma. Arch Ophthalmol. 2008;126:1170.
Oyama T, Takizawa J, Nakamura N, et al. Multifocal mucosa-associated lymphoid tissue lymphoma associated with IgG4-related disease: a case report. Jpn J Ophthalmol. 2011;55:304–6.
Sato Y, Takata K, Ichimura K, et al. IgG4-producing marginal zone B-cell lymphoma. Int J Hematol. 2008;88:428–33.
Yamamoto M, Harada S, Ohara M, et al. Clinical and pathological differences between Mikulicz’s disease and Sjögren’s syndrome. Rheumatology. 2005;44:227–34.
Takahira M, Kawano M, Zen Y, et al. IgG4-related chronic sclerosing dacryoadenitis. Arch Ophthalmol. 2007;125:1575–8.
Kubota T, Moritani S, Katayama M, Terasaki H. Ocular adnexal IgG4-related lymphoplasmacytic infiltrative disorder. Arch Ophthalmol. 2010;128:577–84.
Wallace ZS, Khosroshahi A, Jakobiec FA, et al. IgG4-related systemic disease as a cause of “idiopathic” orbital inflammation, including orbital myositis, and trigeminal nerve involvement. Surv Ophthalmol. 2012;57:26–33.
Kubota T, Moritani S, Terasaki H. Ocular adnexal IgG4-related lymphoplasmacytic infiltrative disorder and Graves ophthalmopathy. Arch Ophthalmol. 2011;129:818–9.
Mehta M, Jakobiec F, Fay A. Idiopathic fibroinflammatory disease of the face, eyelids, and periorbital membrane with immunoglobulin G4-positive plasma cells. Arch Pathol Lab Med. 2009;133:1251–5.
Katsura M, Morita A, Horiuchi H, et al. IgG4-related inflammatory pseudotumor of the trigeminal nerve: another component of IgG4-related sclerosing disease? Am J Neuroradiol. 2011;32:E150–2.
Suzuki M, Mizumachi T, Morita S, Kubota K, Iizuka K. A case of immunoglobulin 4-related disease with bilateral mass-forming lesions in the nasolacrimal ducts. J Clin Rheumatol. 2011;17:207–10.
Batra R, Mudhar HS, Sandramouli S. A unique case of IgG4 sclerosing dacryocystitis. Ophthal Plast Reconstr Surg. 2012;28:e70–2.
Ohno K, Sato Y, Ohshima KI, Takata K, Ando M, Abd Al-Kader L, Iwaki N, Takeuchi M, Orita Y, Yoshino T. IgG4-related disease involving the sclera. Mod Rheumatol. 2012 Sep 16. [Epub ahead of print]
Stone JH, Khosroshahi A, Deshpande V, et al. IgG4-Related disease: recommendations for the nomenclature of this condition and its individual organ system manifestations. Arthritis Rheum. 2012;64:3061–7.
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Takahira, M., Azumi, A. (2014). Ophthalmology. In: Umehara, H., Okazaki, K., Stone, J., Kawa, S., Kawano, M. (eds) IgG4-Related Disease. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54228-5_12
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DOI: https://doi.org/10.1007/978-4-431-54228-5_12
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