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Downregulation of Dullard Expression Enhances BMP-Dependent Neuritogenesis in PC12 Cells

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Interface Oral Health Science 2011

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Abstract

The protein phosphatase dullard negatively regulates bone morphogenetic protein (BMP) signaling by promoting the dephosphorylation or degradation of BMP receptors. We investigated the effects of endogenous dullard downregulation on BMP-induced neuritogenesis in a rat PC12 cell line to assess the basic role of dullard in mammalian neuronal differentiation.

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References

  1. Iwasaki S, Iguchi M, Watanabe K et al (1999) (1992) Specific activation of the p38 mitogen-activated protein kinase signaling pathway and induction of neurite outgrowth in PC12 cells by bone morphogenetic protein-2. J Biol Chem 274:26503–26510

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  2. Satow R, Kurisaki A, Chan TC et al (2006) Dullard promotes degradation and dephosphorylation of BMP receptors and is required for neural induction. Dev Cell 11:763–777

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  3. Zhao F, Kudo T, Zhang Y et al (2010) Role of the protein serine/threonine phosphatase dullard in cell differentiation. Interface Oral Health Science 2009:196–198

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Authors and Affiliations

  1. Department of Physical Medicine and Rehabilitation, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Ye Zhang & Hiroyasu Kanetaka

  2. Division of Oral Physiology, Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Tada-aki Kudo

  3. Division of Oral Pathology, Tohoku University Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Yoshinaka Shimizu

  4. Division of Oral and Craniofacial Anatomy, Tohoku University Graduate School of Dentistry, Tohoku University, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Mitsuhiro Kano

  5. Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Yuya Sano & Hiroyasu Kanetaka

Authors
  1. Ye Zhang
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  2. Tada-aki Kudo
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  3. Yoshinaka Shimizu
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  4. Mitsuhiro Kano
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  5. Yuya Sano
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  6. Hiroyasu Kanetaka
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Corresponding author

Correspondence to Tada-aki Kudo .

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Editors and Affiliations

  1. Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Keiichi Sasaki D.D.S., Ph.D. (Dean and Professor), Osamu Suzuki Ph.D., M.Eng. (Professor) & Nobuhiro Takahashi D.D.S., Ph.D. (Vice-Dean and Professor) (Dean and Professor),  (Professor) &  (Vice-Dean and Professor)

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© 2012 Springer

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Zhang, Y., Kudo, Ta., Shimizu, Y., Kano, M., Sano, Y., Kanetaka, H. (2012). Downregulation of Dullard Expression Enhances BMP-Dependent Neuritogenesis in PC12 Cells. In: Sasaki, K., Suzuki, O., Takahashi, N. (eds) Interface Oral Health Science 2011. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54070-0_44

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  • DOI: https://doi.org/10.1007/978-4-431-54070-0_44

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-54069-4

  • Online ISBN: 978-4-431-54070-0

  • eBook Packages: MedicineMedicine (R0)

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