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Effects of Capsaicin Treatment on Nociception and Structure of Trigeminal Nerve Fibers in Adult Rats

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Interface Oral Health Science 2011

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Abstract

Systemic capsaicin treatment has been used in animal research to eliminate sensory nerve function, but little is known about physiological and morphological effects. We investigated the time-dependent changes in nociception and the ultrastructure of sensory nerve fibers after administration of capsaicin in rats. Capsaicin treatment caused transient loss of sensitivity, but transmission electron microscopy showed no structural changes of trigeminal nerve fibers in capsaicin-treated rats as well as controls. These results suggest that the structural damage to sensory nerve fibers may not be a cause of the reduction of sensitivity.

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References

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Authors and Affiliations

  1. Division of Oral Surgery, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Akiko Kato & Seishi Echigo

  2. Division of Craniofacial Development and Regeneration, Tohoku University Graduate School of Dentistry, Sendai, 980-8575, Japan

    Akiko Kato, Megumi Nakamura & Yasuyuki Sasano

Authors
  1. Akiko Kato
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  2. Megumi Nakamura
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  3. Seishi Echigo
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  4. Yasuyuki Sasano
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Corresponding author

Correspondence to Megumi Nakamura .

Editor information

Editors and Affiliations

  1. Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Keiichi Sasaki D.D.S., Ph.D. (Dean and Professor), Osamu Suzuki Ph.D., M.Eng. (Professor) & Nobuhiro Takahashi D.D.S., Ph.D. (Vice-Dean and Professor) (Dean and Professor),  (Professor) &  (Vice-Dean and Professor)

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© 2012 Springer

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Kato, A., Nakamura, M., Echigo, S., Sasano, Y. (2012). Effects of Capsaicin Treatment on Nociception and Structure of Trigeminal Nerve Fibers in Adult Rats. In: Sasaki, K., Suzuki, O., Takahashi, N. (eds) Interface Oral Health Science 2011. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54070-0_34

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  • DOI: https://doi.org/10.1007/978-4-431-54070-0_34

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-54069-4

  • Online ISBN: 978-4-431-54070-0

  • eBook Packages: MedicineMedicine (R0)

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