Abstract
Various biomaterials that provide a structural scaffold and a micro-spatial environment have been developed for bone regeneration. However, the effects of the size of the micro-space available for osteoblasts are not known. Using a photolithographic technique, the effects of the micro-spatial environment on osteoblast proliferation and differentiation were investigated in cultures plated on modified patterned surfaces. The results suggest that optimal space for osteoblasts is important for osteogenesis. Furthermore, molecules that recognize the extracellular environment related to cell adhesion and movement, might be involved in micro-space-induced osteoblast osteogenesis.
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Acknowledgememts
The authors acknowledge a Grant-in-Aid for Scientific Research (C) 22592278 (to M.C.) from Japanase Ministry of Education, Science, Sports, and Culture.
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© 2012 Springer
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Chiba, M., Miyai, R., Hayashi, H. (2012). Micro-spatial Environment and Osteoblast Osteogenesis. In: Sasaki, K., Suzuki, O., Takahashi, N. (eds) Interface Oral Health Science 2011. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54070-0_23
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DOI: https://doi.org/10.1007/978-4-431-54070-0_23
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-54069-4
Online ISBN: 978-4-431-54070-0
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