Skip to main content
SpringerLink
Log in
Book cover

Interface Oral Health Science 2011 pp 104–106Cite as

Roles of IL-6 in Mastication in Mice and Effects of Training and Food Hardness

  • Conference paper

  • 527 Accesses

Abstract

Upon exercise, IL-6 produced by skeletal muscles plays a key role in glucose homeostasis in skeletal muscles during physical exercise. In this article, the role of IL-6 in masticatory activity (MA) were reviewed, especially in the unique model of gnawing behavior (GB) in mice. GB induced IL-6 mRNA expression in masseter muscles and also increased SOCS-3 mRNA expression, a downstream molecule of IL-6 signaling. Interestingly, mice fed with harder pellet food exhibited higher MA and also lower IL-6 mRNA expression in masseter muscle. IL-6-deficient mice exhibited much lower MA. In addition, in masseter muscle, the recovery of glycogen level after GB and the Glut4 mRNA expressions were lower in ­IL-6-deficient mice.

Taken together, IL-6 produced in masseter muscle in response to mastication plays a key role in sustaining normal masticatory activity by supporting glucose homeostasis, and that daily provision of hard food increases MA, with a decreasing dependency on IL-6 production.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Pedersen BK, Steensberg A, Schjerling P (2001) Muscle-derived interleukin-6: possible biological effects. J Physiol 536:329–337, Review

    Article  PubMed  Google Scholar 

  2. Ayada K, Watanabe M, Endo Y (2000) Elevation of histidine decarboxylase activity in skeletal muscles and stomach in mice by stress and exercise. Am J Physiol Regul Integr Comp Physiol 279:R2042–R2047

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Aging and Geriatric Dentistry, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Masahiro Tsuchiya

  2. Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Tomomi Kiyama & Keiichi Sasaki

  3. Division of Oral Dysfunction Science, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Shinobu Tsuchiya

  4. Environmental Health Sciences Division, National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, 305-8506, Japan

    Hirohisa Takano

  5. Division of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Eiji Nemoto

  6. Division of Oral Immunology, Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Shunji Sugawara & Yasuo Endo

  7. Department of Health Services Management, Tohoku Fukushi University, Kansei Fukushi Research Center, 6-149-1, Kunimigaoka, Aoba-ku, Sendai, 989-3201, Japan

    Makoto Watanabe

Authors
  1. Masahiro Tsuchiya
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Tomomi Kiyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shinobu Tsuchiya
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hirohisa Takano
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Eiji Nemoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Keiichi Sasaki
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Shunji Sugawara
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yasuo Endo
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Makoto Watanabe
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Masahiro Tsuchiya .

Editor information

Editors and Affiliations

  1. Tohoku University Graduate School of Dentistry, 4-1 Seiryo-machi, Aoba-ku, Sendai, 980-8575, Japan

    Keiichi Sasaki D.D.S., Ph.D. (Dean and Professor), Osamu Suzuki Ph.D., M.Eng. (Professor) & Nobuhiro Takahashi D.D.S., Ph.D. (Vice-Dean and Professor) (Dean and Professor),  (Professor) &  (Vice-Dean and Professor)

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer

About this paper

Cite this paper

Tsuchiya, M. et al. (2012). Roles of IL-6 in Mastication in Mice and Effects of Training and Food Hardness. In: Sasaki, K., Suzuki, O., Takahashi, N. (eds) Interface Oral Health Science 2011. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54070-0_21

Download citation

  • DOI: https://doi.org/10.1007/978-4-431-54070-0_21

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-54069-4

  • Online ISBN: 978-4-431-54070-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation