Abstract
Few adequate animal models exist for metal-allergies. However, we previously found that lipopolysaccharide (LPS) promote metal-allergies in mice, and we thereby established a reproducible murine metal-allergy model. Information concerning cross-reactivity among metals is still insufficient, especially lacking the studies in vivo. Here, we used this murine model to examine allergic cross-reactions among some metals. In the experiments using ultra-pure metals (Ni, Pd, Co, Cr, and Cu), Ni and Pd cross-reacted, and their minimum allergy-inducing concentrations were similar. However, there were no cross-reactions among other tested metals. Surprisingly, in the experiments using low-purity metals, all the tested metals (Ni, Pd, Co, Cr, and Cu) cross-reacted. Our findings suggest that there is cross-reactivity between Ni and Pd in the tested metal (Ni, Pd, Co, Cr, and Cu) and high-purity metal salts should be considered for use in clinical patch-testing.
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References
Sato N, Kinbara M, Kuroishi T et al (2007) Liopolysaccharide promotes and augments metal allergies in mice, dependent on innate immunity and histidine decarboxylase. Clin Exp Allergy 37:743–751
Kinbara M, Sato N, Kuroishi T et al (2011) Allergy-inducing nickel concentration is lowered by lipopolysaccharide at both the sensitization and elicitation steps in a murine model. Br J Dermatol 164(2):356–362
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Kinbara, M., Nagai, Y., Takano-Yamamoto, T., Sugawara, S., Endo, Y. (2012). Metal–Allergy Cross-Reactions in Mice. In: Sasaki, K., Suzuki, O., Takahashi, N. (eds) Interface Oral Health Science 2011. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54070-0_17
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DOI: https://doi.org/10.1007/978-4-431-54070-0_17
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-54069-4
Online ISBN: 978-4-431-54070-0
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