Column 3. Anaplastic Transformation of Differentiated Carcinoma

  • Masahisa Saikawa
  • Haruki Akasu


Rapidly enlarging, hard, immobile tumor, prominent dyspnea, and difficulty swallowing are indicative of anaplastic transformation of differentiated carcinoma. Anaplastic transformation can occur in metastatic lymph nodes and metastatic target organs.


Lymph Node Metastasis Thyroid Cancer Metastatic Lymph Node Differentiate Thyroid Cancer Term Survival 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Naito S, Matsui K, Otani N et al (2002) (Text in Japanese) Jibiinkouka Rinsho supplement 109:148–152 (CaseR)Google Scholar
  2. 2.
    Sakai A, Sugitani I, Kawabata K et al (2007) (Text in Japanese) Naibunpitu Geka 24:151–155 (CaseR)Google Scholar
  3. 3.
    Ito Y, Higashiyama T, Hirokawa M et al (2008) Prognosis of patients with papillary carcinoma showing anaplastic transformation in regional lymph nodes that were curatively resected. Endocr J 55:985–989 (RS)PubMedCrossRefGoogle Scholar
  4. 4.
    Inuzuka K, Fujisaki M, Tokura H et al (2004) (Text in Japanese) Rinsho Geka 59:767–771 (CaseR)Google Scholar
  5. 5.
    Aono H, Muto M, Park T et al (2002) (Text in Japanese) Kyotoshi Byouin 22:53–57 (CaseR)Google Scholar
  6. 6.
    Quiros RM, Ding HG, Gattuso P et al (2005) Evidence that one subset of anaplastic thyroid carcinomas are derived from papillary carcinomas due to BRAF and p53 mutations. Cancer 103:2261–2268 (RS)PubMedCrossRefGoogle Scholar
  7. 7.
    Wang HM, Huang YW, Huang JS et al (2007) Anaplastic carcinoma of the thyroid arising more often from follicular carcinoma than papillary carcinoma. Ann Surg Oncol 14:3011–3018 (RS)PubMedCrossRefGoogle Scholar
  8. 8.
    Elliott DD, Sherman SI, Busaidy NL et al (2008) Growth factor receptors expression in anaplastic thyroid carcinoma: potential markers for therapeutic stratification. Hum Pathol 39:15–20 (PS)PubMedCrossRefGoogle Scholar
  9. 9.
    Wiseman SM, Griffith OL, Deen S et al (2007) Identification of molecular markers altered during transformation of differentiated into anaplastic thyroid carcinoma. Arch Surg 142:717–729 (PS)PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 2013

Authors and Affiliations

  1. 1.Division of Head and Neck SurgeryNational Center Hospital EastKashiwaJapan
  2. 2.Department of Surgery, Division of Endocrine SurgeryNippon Medical SchoolTokyoJapan

Personalised recommendations