Column 10. Carcinoma Showing Thymus-Like Differentiation/Intrathyroidal Epithelial Thymoma

  • Yasuhiro Ito
  • Hiroshi Kanma


Carcinoma showing thymus-like differentiation (CASTLE) is a rare malignant epithelial tumor originating from the thymic epithelium resting in the thyroid. It becomes an issue because of the need to histologically differentiate it from squamous cell carcinoma and anaplastic carcinoma, but it shows a comparatively good prognosis with a high rate of surgical curativity.


Tumor Cell Squamous Cell Carcinoma Good Prognosis Spindle Cell Young Subject 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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    DeLellis RA, Llyoid RV, Heinzz PU et al (2004) Pathology & genetics: tumours of endocrine organs. WHO, Lyon, pp 94–97 (Others)Google Scholar
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    Dorfman DM, Shahsafaei A, Miyauchi A (1998) Intrathyroidal epithelial thymoma (ITET)/carcinoma showing thymus-like differentiation (CASTLE) exhibits CD5 immunoreactivity: new evidence for thymic differentiation. Histopathology 32:104–109 (RS)PubMedCrossRefGoogle Scholar
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    Reimann JD, Dorfman DM, Nose V (2006) Carcinoma showing thymus-like differentiation of the thyroid (CASTLE): a comparative study: evidence of thymic differentiation and solid cell nest origin. Am J Surg Pathol 30:994–1001 (RS)PubMedCrossRefGoogle Scholar
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    Ito Y, Miyauchi A, Nakamura Y et al (2007) Clinicopathologic significance of intrathyroidal epithelial thymoma/carcinoma showing thymus-like differentiation: a collaborative study with Member Institutes of The Japanese Society of Thyroid Surgery. Am J Clin Pathol 127:230–236 (RS)PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 2013

Authors and Affiliations

  1. 1.Department of SurgeryKuma HospitalKobeJapan
  2. 2.Department of PathologyKyorin University School of MedicineTokyoJapan

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