CQ35. Do Therapies Other Than Surgery Improve the Prognosis for Patients with Poorly Differentiated Carcinoma?



Poorly differentiated carcinoma shows a poor prognosis and there are cases who present with distant metastasis and those who cannot undergo locally curative surgery. The significance of treatments other than surgery for such patients was investigated.


Distant Metastasis Local Control Thyroid Carcinoma Lung Metastasis External Beam Radiotherapy 


  1. 1.
    Justin EP, Seahold JE, Robinson RA et al (1991) Insular carcinoma: a distinct thyroid carcinoma with associated iodine-131 localization. J Nucl Med 32:1358–1363 (RS)PubMedGoogle Scholar
  2. 2.
    Hiltzik D, Carlson DL, Tuttle M et al (2006) Poorly differentiated thyroid carcinomas defined on the basis of mitosis and necrosis: a clinicopathologic study of 58 patients. Cancer 106:1286–1295 (RS)PubMedCrossRefGoogle Scholar
  3. 3.
    Patel KN, Shaha AR (2006) Poorly differentiated and anaplastic thyroid cancer. Cancer Control 13:119–128 (RS)PubMedGoogle Scholar
  4. 4.
    Sanders EM Jr, LiVolsi V, Brierley J (2007) An evidence-based review of poorly differentiated thyroid cancer. World J Surg 31:934–945 (NR)PubMedCrossRefGoogle Scholar
  5. 5.
    Lin JD, Chao TC, Hsueh C (2007) Clinical characteristics of poorly differentiated thyroid carcinomas compared with those of classical papillary thyroid carcinomas. Clin Endocrinol (Oxf) 66:224–228 (RS)CrossRefGoogle Scholar
  6. 6.
    Volante M, Landolfi S, Chiusa L et al (2004) Poorly differentiated carcinomas of the thyroid with trabecular, insular, and solid patterns. Cancer 100:950–957 (RS)PubMedCrossRefGoogle Scholar
  7. 7.
    Jung TS, Kim TY, Kim KW et al (2007) Clinical features and prognostic factors for survival in patients with poorly differentiated thyroid carcinoma and comparison to the patients with the aggressive variants of papillary thyroid carcinoma. Endocr J 54:265–274 (RS)PubMedCrossRefGoogle Scholar
  8. 8.
    Lai HW, Lee CH, Chen JY et al (2006) Insular thyroid carcinoma: collective analysis of clinicohistologic prognostic factors and treatment effect with radioiodine or radiation therapy. J Am Coll Surg 203:715–722 (RS, NR)PubMedCrossRefGoogle Scholar
  9. 9.
    Auersperg M, Us-Krasovec M, Petric G et al (1990) Results of combined modality treatment in poorly differentiated and anaplastic thyroid carcinoma. Wien Klin Woschenschr 27:267–270 (RS)Google Scholar
  10. 10.
    Santini F, Bottici V, Elisei L (2002) Cytotoxic effects of carbolatinum and epirubicin in the setting of an elevated werum thyrotropin for advanced poorly differentiated thyroid cancer. J Clin Endocrinol Metab 87:4160–4165 (RS)PubMedCrossRefGoogle Scholar

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© Springer Japan 2013

Authors and Affiliations

  1. 1.Department of SurgeryKuma HospitalKobeJapan
  2. 2.Department of PathologyKyorin University School of MedicineTokyoJapan

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