Abstract
We studied the literature for the effectiveness of chemotherapy on advanced or relapsed medullary thyroid carcinoma with no indications for surgery, where tangible tumors were detectable on palpation or imaging studies. Serum cacitonin level and CEA level are sensitive tumor markers of medullary carcinoma and these elevations are often initial signs of recurrence before findings on imaging studies, but no reports are available for chemotherapy for cases without relapsed tumors for which sizes can be measured.
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References
Petursson SR (1988) Metastatic medullary thyroid carcinoma: complete response to combination chemotherapy with dacarbazine and 5-fluorouracil. Cancer 62:1899–1903 (CR)
Gottlieb JA, Hill CS Jr (1974) Chemotherapy of thyroid cancer with adriamycin. Experience with 30 patients. N Engl J Med 290:193–197 (RS)
Shimaoka K, Schoenfeld DA, DeWys WD et al (1985) A randomized trial of doxorubicin versus doxorubicin plus cisplatin in patients with advanced thyroid carcinoma. Cancer 56:2155–2160 (RCT)
Scherübl H, Raue F, Ziegler R (1990) Combination chemotherapy of advanced medullary and differentiated thyroid cancer. Phase II study. J Cancer Res Clin Oncol 116:21–23 (PS)
Orlandi F, Caraci P, Berruti B et al (1994) Chemotherapy with dacarbazine and 5-fluorouracil in advanced medullary thyroid cancer. Ann Oncol 5:763–765 (RS)
Wu LT, Averbuch SD, Ball DW et al (1994) Treatment of advanced medullary thyroid carcinoma with a combination of cyclophosphamide, vincristine, and dacarbazine. Cancer 73:432–436 (RS)
Schlumberger M, Abdelmoumene N, Delisle MJ et al (1995) Treatment of advanced medullary thyroid cancer with an alternating combination of 5 FU-streptozocin and 5 FU-dacarbazine. Br J Cancer 71:363–365 (unknown study design)
Nocera M, Baudin E, Pellegriti G et al (2000) Treatment of advanced medullary thyroid cancer with an alternating combination of doxorubicin-streptozocin and 5 FU-dacarbazine. Br J Cancer 83:715–718 (RS)
Matuszczyk A, Petersenn S, Bockisch A et al (2008) Chemotherapy with doxorubicin in progressive medullary and thyroid carcinoma of the follicular epithelium. Horm Metab Res 40:210–213 (RS)
Lorenz K, Brauckhoff M, Behrmann C et al (2005) Selective arterial chemoembolization for hepatic metastases from medullary thyroid carcinoma. Surgery 138:986–993 (PS)
Fromigué J, De Baere T, Baudin E et al (2006) Chemoembolization for liver metastases from medullary thryoid carcinoma. J Clin Endocrinol Metab 91:2496–2499 (PS)
Lupoli G, Cascone E, Arlotta F et al (1996) Treatment of advanced medullary thyroid carcinoma with a combination of recombiant interferon alpha-2b and octreotide. Cancer 78:1114–1118 (RS)
Mahler C, Verhelst J, De Longueville M et al (1990) Long-term treatment of metastatic medullary thyroid carcinoma with the somatostatin analogue octreotide. Clin Endocrinol 33:261–269 (RS)
Modigliani E, Cohen R, Joannidis S et al (1992) Results of long-term continuous subcutaneous ocreotide administration in 14 patients with medullary thyroid carcinoma. Clin Endocrinol 36:183–186 (RS)
Diez JJ, Iglesias P (2002) Somatostatin analogs in the treatment of medullary thyroid carcinoma. J Endocrinol Invest 25:773–778 (RS)
Vitale G, Tagliaferri P, Caraglia M et al (2000) Slow release lanreotide in combination with interferon-alpha 2b in the treatment of symptomatic advanced medullary thyroid carcinoma. J Clin Endocrinol Metab 85:983–988 (unknown study design)
British Thyroid Associations & Royal College of Physicians (2007) Guidelines for the management of thyroid cancer in adults, 2nd edn. www.british-thyroid-association.org
Cooper DS, Doherty GM, Haugen BR et al (2006) American Thyroid Association Guidelines Taskforce. Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 16:109–142, http://www.thyroid.org/professionals/publications/documents/Guidelinesthy2006.pdf
NCCN Clinical Practice Guidelines in Oncology: Thyroid Carcinoma (2009) v1. http://www.nccn.org/professionals/physician_gls/PDF/thyroid.pdf
Kloos RT, Eng C, Evans DB et al (2009) Medullary thyroid cancer: management guidelines of the American Thyroid Association. Thyroid 19:565–612, http://www.thyroid.org/professionals/publications/documents/MTC_Guidelines.pdf
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Uchino, S., Miura, D., Okamoto, T. (2013). CQ29. Is Chemotherapy Effective for Advanced or Relapsed Medullary Carcinoma?. In: Takami, H., Ito, Y., Noguchi, H., Yoshida, A., Okamoto, T. (eds) Treatment of Thyroid Tumor. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54049-6_40
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DOI: https://doi.org/10.1007/978-4-431-54049-6_40
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