CQ25. Does Prognosis of Oxyphilic (Hurthle Cell) Follicular Carcinoma Differ from That of Conventional Follicular Carcinoma?

  • Kaoru Kobayashi
  • Akira Yoshida
  • Takehito Igarashi


Follicular carcinoma (oxyphilic cell variant) also known as Hurthle cell carcinoma, is defined as a particular type of follicular carcinoma in the WHO classification and “General Rules for the Description of Thyroid Cancer” in Japan. The section surface of the tumor is reddish brown (brick color) and is usually associated with bleeding, cysts, fibrous structure, and infarction. Wide cytoplasms with eosinophilic granules and clear nuclear bodies are detected on H–E staining. By electron microscopy, cytoplasms filled by abundant mitochondria are observed. In the past, oxyphilic cell variant was claimed to be a separate entity from conventional follicular carcinoma. Others have claimed that there is no such thing as a benign oxyphilic tumor and that they always have malignant potential. Follicular carcinoma of this type is very rare in Japan. It is classified into a particular variant because its biological characteristics significantly differ from conventional follicular carcinoma. For a long time, there has been a debate on whether the prognosis of oxyphilic cell variant differs from that of conventional carcinoma [1].


Thyroid Cancer Papillary Carcinoma Malignant Potential Iodine Deficiency Separate Entity 
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Copyright information

© Springer Japan 2013

Authors and Affiliations

  • Kaoru Kobayashi
    • 1
  • Akira Yoshida
    • 2
  • Takehito Igarashi
    • 3
  1. 1.Department of SurgeryKuma HospitalKobeJapan
  2. 2.Department of Breast and Endocrine SurgeryKanagawa Cancer CenterYokohamaJapan
  3. 3.Department of Surgery, Division of Endocrine SurgeryNippon Medical SchoolTokyoJapan

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