Multinodular goiter is a frequently seen thyroid disease, but it is usually a hyperplastic lesion that is called adenomatous goiter, indicating that, in principle, surgery is not necessary unless clinical manifestations become clearly apparent. However, in practice, these nodules are often difficult to distinguish from follicular tumor and papillary carcinoma occasionally coexists. FNA is performed for the largest nodule or nodules suspected of malignancy in many specialist hospitals, and observation continues when the results are negative. Thus, this CQ investigates the possibility of surgical resection for multinodular goiter after observation.
Thyroid Disease Papillary Carcinoma Specialist Hospital Multinodular Goiter Large Nodule
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in to check access
Vander JB, Gaston EA, Dawber TR (1968) The significance of nontoxic thyroid nodules. Final report of a 15-year study of the incidence of thyroid malignancy. Ann Intern Med 69:537–540 (PS)PubMedGoogle Scholar
Frates MC, Benson CB, Doubilet PM et al (2006) Prevalence and distribution of carcinoma in patients with solitary and multiple thyroid nodules on sonography. J Clin Endocrinol Metab 91:3411–3417 (RS)PubMedCrossRefGoogle Scholar
Ríos A, Rodríguez JM, Galindo PJ et al (2004) Utility of fine-needle aspiration for diagnosis of carcinoma associated with multinodular goitre. Clin Endocrinol (Oxf) 61:732–737 (RS)CrossRefGoogle Scholar
Tollin SR, Mery GM, Jelveh N et al (2000) The use of fine needle aspiration biopsy under ultrasound guidance to assess the risk of malignancy. Thyroid 10:235–241 (RS)PubMedCrossRefGoogle Scholar
Merchant SH, Izquierdo R, Khurana KK (2000) Is repeated fine-needle aspiration cytology useful in the management of patients with benign nodular thyroid disease? Thyroid 10:489–492 (RS)PubMedGoogle Scholar
Orlandi A, Puscar A, Capriata E et al (2005) Repeated fine-needle aspiration of the thyroid in benign nodular thyroid disease: critical evaluation of long-term follow-up. Thyroid 15:274–278 (RS)PubMedCrossRefGoogle Scholar
Liel Y, Ariad S, Barchana M (2001) Long-term follow-up of patients with initially benign thyroid fine-needle aspirations. Thyroid 11:775–778 (RS)PubMedCrossRefGoogle Scholar
Kuma K, Matsuzuka F, Yokozawa T et al (1994) Fate of untreated benign thyroid nodules: results of long-term follow-up. World J Surg 18:495–498 (PS)PubMedCrossRefGoogle Scholar
Elte JW, Bussemaker JK, Haak A (1990) The natural history of euthyroid mulinodular goitre. Postgrad Med J 66:186–190 (RS)PubMedCrossRefGoogle Scholar
Bonnema SJ, Bennedbaek FN, Ladenson PW et al (2002) Management of the nontoxic multinodular goiter: a North American survey. J Clin Endocrinol Metab 87:112–117 (Others)PubMedCrossRefGoogle Scholar
Bonnema SJ, Bennedbaek FN, Wiersinga WM et al (2000) Management of the nontoxic multinodular goiter: a European questionnaire study. Clin Endocrinol (Oxf) 53:5–12 (Others)CrossRefGoogle Scholar
Copper DS, Doherty GM, Haugen BR et al (2006) Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 16:109–142 (SR<RS>)CrossRefGoogle Scholar